Phase resetting of the mammalian circadian clock relies on a rapid shift of a small population of pacemaker neurons

The circadian pacemaker of the suprachiasmatic nuclei (SCN) contains a major pacemaker for 24 h rhythms that is synchronized to the external light-dark cycle. In response to a shift in the external cycle, neurons of the SCN resynchronize with different pace. We performed electrical activity recordin...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2011-09, Vol.6 (9), p.e25437-e25437
Main Authors: Rohling, Jos H T, vanderLeest, Henk Tjebbe, Michel, Stephan, Vansteensel, Mariska J, Meijer, Johanna H
Format: Article
Language:English
Subjects:
Animals
Biological clocks
Biology
Circadian Clocks - physiology
Circadian rhythm
Circadian rhythms
Comparative analysis
Curve fitting
Electrophysiology
Gene expression
Laboratories
Light
Male
Mammals
Microscopy
Neurons
Neurons - cytology
Neurons - physiology
Phase distribution
Polypeptides
Predictions
Quantitative analysis
Rats
Rats, Wistar
Rodents
Subpopulations
Suprachiasmatic Nucleus - cytology
Synchronism
Synchronization
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c691t-eca5ad1b0dcd5083f4cf4df413d2730394136504ad930882f4676ac9e2b1b0003
cites
container_end_page e25437
container_issue 9
container_start_page e25437
container_title PloS one
container_volume 6
creator Rohling, Jos H T
vanderLeest, Henk Tjebbe
Michel, Stephan
Vansteensel, Mariska J
Meijer, Johanna H
description The circadian pacemaker of the suprachiasmatic nuclei (SCN) contains a major pacemaker for 24 h rhythms that is synchronized to the external light-dark cycle. In response to a shift in the external cycle, neurons of the SCN resynchronize with different pace. We performed electrical activity recordings of the SCN of rats in vitro following a 6 hour delay of the light-dark cycle and observed a bimodal electrical activity pattern with a shifted and an unshifted component. The shifted component was relatively narrow as compared to the unshifted component (2.2 h and 5.7 h, respectively). Curve fitting and simulations predicted that less than 30% of the neurons contribute to the shifted component and that their phase distribution is small. This prediction was confirmed by electrophysiological recordings of neuronal subpopulations. Only 25% of the neurons exhibited an immediate shift in the phase of the electrical activity rhythms, and the phases of the shifted subpopulations appeared significantly more synchronized as compared to the phases of the unshifted subpopulations (p
doi_str_mv 10.1371/journal.pone.0025437
format article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1308616794</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A476877952</galeid><doaj_id>oai_doaj_org_article_dec60b3468f6490e85f571f0475f314f</doaj_id><sourcerecordid>A476877952</sourcerecordid><originalsourceid>FETCH-LOGICAL-c691t-eca5ad1b0dcd5083f4cf4df413d2730394136504ad930882f4676ac9e2b1b0003</originalsourceid><addsrcrecordid>eNqNk11rFDEUhgdRbK3-A9GAoHixazLJJDM3Qil-LBQqft2Gs_nYSZuZTJMZ0X9vtrstO9ILyUUOJ8_7JjnJKYrnBC8JFeTdZZhiD345hN4sMS4rRsWD4pg0tFzwEtOHB_FR8SSlS4wrWnP-uDgqScN5VTbHRfrSQjIommTG0fUbFCwaW4M66DrwDnqkXFSgbyIf1FVGvTMJhR4BijA4jVLr7LgVAkpZ5NEQhsnD6DKTswMo08GViag3Uwx9elo8suCTebafT4ofHz98P_u8OL_4tDo7PV8o3pBxYRRUoMkaa6UrXFPLlGXaMkJ1KSimTY54hRnohuK6Li3jgoNqTLnOIozpSfFy5zv4kOS-XkmSTHPCRcMysdoROsClHKLrIP6RAZy8SYS4kRBHp7yR2iiO15Tx2nLWYFNXthLEYiYqSwmz2ev9frdp3RmtTD9G8DPT-UrvWrkJvyQloua0yQZv9gYxXE8mjbJzSRnvoTdhSrJueMlETetMvvqHvP9ye2oD-fyutyFvq7ae8pQJXgvRVGWmlvdQeWjTOZX_lnU5PxO8nQkyM5rf4wamlOTq29f_Zy9-ztnXB2xrwI9tCn7afqM0B9kOVDGkFI29qzHBctsat9WQ29aQ-9bIsheH73Mnuu0F-hfAnglD</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1308616794</pqid></control><display><type>article</type><title>Phase resetting of the mammalian circadian clock relies on a rapid shift of a small population of pacemaker neurons</title><source>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</source><source>PubMed Central Free</source><creator>Rohling, Jos H T ; vanderLeest, Henk Tjebbe ; Michel, Stephan ; Vansteensel, Mariska J ; Meijer, Johanna H</creator><contributor>Yamazaki, Shin</contributor><creatorcontrib>Rohling, Jos H T ; vanderLeest, Henk Tjebbe ; Michel, Stephan ; Vansteensel, Mariska J ; Meijer, Johanna H ; Yamazaki, Shin</creatorcontrib><description>The circadian pacemaker of the suprachiasmatic nuclei (SCN) contains a major pacemaker for 24 h rhythms that is synchronized to the external light-dark cycle. In response to a shift in the external cycle, neurons of the SCN resynchronize with different pace. We performed electrical activity recordings of the SCN of rats in vitro following a 6 hour delay of the light-dark cycle and observed a bimodal electrical activity pattern with a shifted and an unshifted component. The shifted component was relatively narrow as compared to the unshifted component (2.2 h and 5.7 h, respectively). Curve fitting and simulations predicted that less than 30% of the neurons contribute to the shifted component and that their phase distribution is small. This prediction was confirmed by electrophysiological recordings of neuronal subpopulations. Only 25% of the neurons exhibited an immediate shift in the phase of the electrical activity rhythms, and the phases of the shifted subpopulations appeared significantly more synchronized as compared to the phases of the unshifted subpopulations (p&lt;0.05). We also performed electrical activity recordings of the SCN following a 9 hour advance of the light-dark cycle. The phase advances induced a large desynchrony among the neurons, but consistent with the delays, only 19% of the neurons peaked at the mid of the new light phase. The data suggest that resetting of the central circadian pacemaker to both delays and advances is brought about by an initial shift of a relatively small group of neurons that becomes highly synchronized following a shift in the external cycle. The high degree of synchronization of the shifted neurons may add to the ability of this group to reset the pacemaker. The large desynchronization observed following advances may contribute to the relative difficulty of the circadian system to respond to advanced light cycles.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0025437</identifier><identifier>PMID: 21966529</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Biological clocks ; Biology ; Circadian Clocks - physiology ; Circadian rhythm ; Circadian rhythms ; Comparative analysis ; Curve fitting ; Electrophysiology ; Gene expression ; Laboratories ; Light ; Male ; Mammals ; Microscopy ; Neurons ; Neurons - cytology ; Neurons - physiology ; Phase distribution ; Polypeptides ; Predictions ; Quantitative analysis ; Rats ; Rats, Wistar ; Rodents ; Subpopulations ; Suprachiasmatic Nucleus - cytology ; Synchronism ; Synchronization</subject><ispartof>PloS one, 2011-09, Vol.6 (9), p.e25437-e25437</ispartof><rights>COPYRIGHT 2011 Public Library of Science</rights><rights>2011 Rohling et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Rohling et al. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c691t-eca5ad1b0dcd5083f4cf4df413d2730394136504ad930882f4676ac9e2b1b0003</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1308616794/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1308616794?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21966529$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Yamazaki, Shin</contributor><creatorcontrib>Rohling, Jos H T</creatorcontrib><creatorcontrib>vanderLeest, Henk Tjebbe</creatorcontrib><creatorcontrib>Michel, Stephan</creatorcontrib><creatorcontrib>Vansteensel, Mariska J</creatorcontrib><creatorcontrib>Meijer, Johanna H</creatorcontrib><title>Phase resetting of the mammalian circadian clock relies on a rapid shift of a small population of pacemaker neurons</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The circadian pacemaker of the suprachiasmatic nuclei (SCN) contains a major pacemaker for 24 h rhythms that is synchronized to the external light-dark cycle. In response to a shift in the external cycle, neurons of the SCN resynchronize with different pace. We performed electrical activity recordings of the SCN of rats in vitro following a 6 hour delay of the light-dark cycle and observed a bimodal electrical activity pattern with a shifted and an unshifted component. The shifted component was relatively narrow as compared to the unshifted component (2.2 h and 5.7 h, respectively). Curve fitting and simulations predicted that less than 30% of the neurons contribute to the shifted component and that their phase distribution is small. This prediction was confirmed by electrophysiological recordings of neuronal subpopulations. Only 25% of the neurons exhibited an immediate shift in the phase of the electrical activity rhythms, and the phases of the shifted subpopulations appeared significantly more synchronized as compared to the phases of the unshifted subpopulations (p&lt;0.05). We also performed electrical activity recordings of the SCN following a 9 hour advance of the light-dark cycle. The phase advances induced a large desynchrony among the neurons, but consistent with the delays, only 19% of the neurons peaked at the mid of the new light phase. The data suggest that resetting of the central circadian pacemaker to both delays and advances is brought about by an initial shift of a relatively small group of neurons that becomes highly synchronized following a shift in the external cycle. The high degree of synchronization of the shifted neurons may add to the ability of this group to reset the pacemaker. The large desynchronization observed following advances may contribute to the relative difficulty of the circadian system to respond to advanced light cycles.</description><subject>Animals</subject><subject>Biological clocks</subject><subject>Biology</subject><subject>Circadian Clocks - physiology</subject><subject>Circadian rhythm</subject><subject>Circadian rhythms</subject><subject>Comparative analysis</subject><subject>Curve fitting</subject><subject>Electrophysiology</subject><subject>Gene expression</subject><subject>Laboratories</subject><subject>Light</subject><subject>Male</subject><subject>Mammals</subject><subject>Microscopy</subject><subject>Neurons</subject><subject>Neurons - cytology</subject><subject>Neurons - physiology</subject><subject>Phase distribution</subject><subject>Polypeptides</subject><subject>Predictions</subject><subject>Quantitative analysis</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Subpopulations</subject><subject>Suprachiasmatic Nucleus - cytology</subject><subject>Synchronism</subject><subject>Synchronization</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11rFDEUhgdRbK3-A9GAoHixazLJJDM3Qil-LBQqft2Gs_nYSZuZTJMZ0X9vtrstO9ILyUUOJ8_7JjnJKYrnBC8JFeTdZZhiD345hN4sMS4rRsWD4pg0tFzwEtOHB_FR8SSlS4wrWnP-uDgqScN5VTbHRfrSQjIommTG0fUbFCwaW4M66DrwDnqkXFSgbyIf1FVGvTMJhR4BijA4jVLr7LgVAkpZ5NEQhsnD6DKTswMo08GViag3Uwx9elo8suCTebafT4ofHz98P_u8OL_4tDo7PV8o3pBxYRRUoMkaa6UrXFPLlGXaMkJ1KSimTY54hRnohuK6Li3jgoNqTLnOIozpSfFy5zv4kOS-XkmSTHPCRcMysdoROsClHKLrIP6RAZy8SYS4kRBHp7yR2iiO15Tx2nLWYFNXthLEYiYqSwmz2ev9frdp3RmtTD9G8DPT-UrvWrkJvyQloua0yQZv9gYxXE8mjbJzSRnvoTdhSrJueMlETetMvvqHvP9ye2oD-fyutyFvq7ae8pQJXgvRVGWmlvdQeWjTOZX_lnU5PxO8nQkyM5rf4wamlOTq29f_Zy9-ztnXB2xrwI9tCn7afqM0B9kOVDGkFI29qzHBctsat9WQ29aQ-9bIsheH73Mnuu0F-hfAnglD</recordid><startdate>20110922</startdate><enddate>20110922</enddate><creator>Rohling, Jos H T</creator><creator>vanderLeest, Henk Tjebbe</creator><creator>Michel, Stephan</creator><creator>Vansteensel, Mariska J</creator><creator>Meijer, Johanna H</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20110922</creationdate><title>Phase resetting of the mammalian circadian clock relies on a rapid shift of a small population of pacemaker neurons</title><author>Rohling, Jos H T ; vanderLeest, Henk Tjebbe ; Michel, Stephan ; Vansteensel, Mariska J ; Meijer, Johanna H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c691t-eca5ad1b0dcd5083f4cf4df413d2730394136504ad930882f4676ac9e2b1b0003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Biological clocks</topic><topic>Biology</topic><topic>Circadian Clocks - physiology</topic><topic>Circadian rhythm</topic><topic>Circadian rhythms</topic><topic>Comparative analysis</topic><topic>Curve fitting</topic><topic>Electrophysiology</topic><topic>Gene expression</topic><topic>Laboratories</topic><topic>Light</topic><topic>Male</topic><topic>Mammals</topic><topic>Microscopy</topic><topic>Neurons</topic><topic>Neurons - cytology</topic><topic>Neurons - physiology</topic><topic>Phase distribution</topic><topic>Polypeptides</topic><topic>Predictions</topic><topic>Quantitative analysis</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Subpopulations</topic><topic>Suprachiasmatic Nucleus - cytology</topic><topic>Synchronism</topic><topic>Synchronization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rohling, Jos H T</creatorcontrib><creatorcontrib>vanderLeest, Henk Tjebbe</creatorcontrib><creatorcontrib>Michel, Stephan</creatorcontrib><creatorcontrib>Vansteensel, Mariska J</creatorcontrib><creatorcontrib>Meijer, Johanna H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints In Context</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest_Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Database‎ (1962 - current)</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest advanced technologies &amp; aerospace journals</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials science collection</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rohling, Jos H T</au><au>vanderLeest, Henk Tjebbe</au><au>Michel, Stephan</au><au>Vansteensel, Mariska J</au><au>Meijer, Johanna H</au><au>Yamazaki, Shin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phase resetting of the mammalian circadian clock relies on a rapid shift of a small population of pacemaker neurons</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2011-09-22</date><risdate>2011</risdate><volume>6</volume><issue>9</issue><spage>e25437</spage><epage>e25437</epage><pages>e25437-e25437</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The circadian pacemaker of the suprachiasmatic nuclei (SCN) contains a major pacemaker for 24 h rhythms that is synchronized to the external light-dark cycle. In response to a shift in the external cycle, neurons of the SCN resynchronize with different pace. We performed electrical activity recordings of the SCN of rats in vitro following a 6 hour delay of the light-dark cycle and observed a bimodal electrical activity pattern with a shifted and an unshifted component. The shifted component was relatively narrow as compared to the unshifted component (2.2 h and 5.7 h, respectively). Curve fitting and simulations predicted that less than 30% of the neurons contribute to the shifted component and that their phase distribution is small. This prediction was confirmed by electrophysiological recordings of neuronal subpopulations. Only 25% of the neurons exhibited an immediate shift in the phase of the electrical activity rhythms, and the phases of the shifted subpopulations appeared significantly more synchronized as compared to the phases of the unshifted subpopulations (p&lt;0.05). We also performed electrical activity recordings of the SCN following a 9 hour advance of the light-dark cycle. The phase advances induced a large desynchrony among the neurons, but consistent with the delays, only 19% of the neurons peaked at the mid of the new light phase. The data suggest that resetting of the central circadian pacemaker to both delays and advances is brought about by an initial shift of a relatively small group of neurons that becomes highly synchronized following a shift in the external cycle. The high degree of synchronization of the shifted neurons may add to the ability of this group to reset the pacemaker. The large desynchronization observed following advances may contribute to the relative difficulty of the circadian system to respond to advanced light cycles.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21966529</pmid><doi>10.1371/journal.pone.0025437</doi><tpages>e25437</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2011-09, Vol.6 (9), p.e25437-e25437
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_1308616794
source Publicly Available Content Database (Proquest) (PQ_SDU_P3); PubMed Central Free
subjects Animals
Biological clocks
Biology
Circadian Clocks - physiology
Circadian rhythm
Circadian rhythms
Comparative analysis
Curve fitting
Electrophysiology
Gene expression
Laboratories
Light
Male
Mammals
Microscopy
Neurons
Neurons - cytology
Neurons - physiology
Phase distribution
Polypeptides
Predictions
Quantitative analysis
Rats
Rats, Wistar
Rodents
Subpopulations
Suprachiasmatic Nucleus - cytology
Synchronism
Synchronization
title Phase resetting of the mammalian circadian clock relies on a rapid shift of a small population of pacemaker neurons
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T15%3A48%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Phase%20resetting%20of%20the%20mammalian%20circadian%20clock%20relies%20on%20a%20rapid%20shift%20of%20a%20small%20population%20of%20pacemaker%20neurons&rft.jtitle=PloS%20one&rft.au=Rohling,%20Jos%20H%20T&rft.date=2011-09-22&rft.volume=6&rft.issue=9&rft.spage=e25437&rft.epage=e25437&rft.pages=e25437-e25437&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0025437&rft_dat=%3Cgale_plos_%3EA476877952%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c691t-eca5ad1b0dcd5083f4cf4df413d2730394136504ad930882f4676ac9e2b1b0003%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1308616794&rft_id=info:pmid/21966529&rft_galeid=A476877952&rfr_iscdi=true