Initial presentations predict mortality in pulmonary tuberculosis patients--a prospective observational study

Despite effective anti-TB treatments, tuberculosis remains a serious threat to public health and is associated with high mortality. Old age and multiple co-morbidities are known risk factors for death. The association of clinical presentations with mortality in pulmonary tuberculosis patients remain...

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Bibliographic Details
Published in:PloS one 2011-09, Vol.6 (9), p.e23715-e23715
Main Authors: Feng, Jia-Yih, Su, Wei-Juin, Chiu, Yu-Chi, Huang, Shiang-Fen, Lin, Yung-Yang, Huang, Ruay-Ming, Lin, Ching-Hsiung, Hwang, Jhi-Jhu, Lee, Jen-Jyh, Yu, Ming-Chih, Yu, Kwok-Woon, Lee, Yu-Chin
Format: Article
Language:English
Subjects:
Aged
Analysis
Anorexia
Clinical medicine
Cough
Demographics
Disease
Drug resistance
Dyspnea
Early experience
Epidemiology
Ethics
Female
Fever
Genotype
Genotype & phenotype
Health care facilities
Health risks
HIV
Hospitals
Human immunodeficiency virus
Humans
Infections
Intensive care
Internal medicine
Kidneys
Male
Malignancy
Medical centers
Medical diagnosis
Medical laboratories
Medical research
Medicine
Middle Aged
Mortality
Mycobacterium - genetics
Mycobacterium tuberculosis
Observational studies
Patient outcomes
Patients
Prognosis
Prospective Studies
Public health
Pulmonary tuberculosis
Renal insufficiency
Respiration
Review boards
Risk analysis
Risk factors
Studies
Survival Rate
Tuberculosis
Tuberculosis, Pulmonary - diagnosis
Tuberculosis, Pulmonary - microbiology
Tuberculosis, Pulmonary - mortality
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Summary:Despite effective anti-TB treatments, tuberculosis remains a serious threat to public health and is associated with high mortality. Old age and multiple co-morbidities are known risk factors for death. The association of clinical presentations with mortality in pulmonary tuberculosis patients remains an issue of controversy. This prospective observational study enrolled newly diagnosed, culture-proven pulmonary tuberculosis patients from five medical centers and one regional hospital, which were referral hospitals of TB patients. Radiographic findings and clinical symptoms were determined at the time of diagnosis. Patients who died for any reason during the course of anti-TB treatment were defined as mortality cases and death that occurred within 30 days of initiating treatment was defined as early mortality. Clinical factors associated with overall mortality and early mortality were investigated. A total of 992 patients were enrolled and 195 (19.7%) died. Nearly one-third (62/195, 31.8%) of the deaths occurred before or within 30 days of treatment initiation. Older age (RR = 1.04, 95%CI: 1.03-1.05), malignancy (RR = 2.42, 95%CI: 1.77-3.31), renal insufficiency (RR = 1.77, 95%CI: 1.12-2.80), presence of chronic cough (RR = 0.63, 95%CI: 0.47-0.84), fever (RR = 1.45, 95%CI: 1.09-1.94), and anorexia (RR = 1.49, 95%CI: 1.07-2.06) were independently associated with overall mortality. Kaplan-Meier survival analysis demonstrated significantly higher mortality in patients present with fever (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0023715