Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure

Heart failure (HF) is characterized by contractile dysfunction associated with altered energy metabolism. This study was aimed at determining whether resveratrol, a polyphenol known to activate energy metabolism, could be beneficial as a metabolic therapy of HF. Survival, ventricular and vascular fu...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2011-10, Vol.6 (10), p.e26391-e26391
Main Authors: Rimbaud, Stéphanie, Ruiz, Matthieu, Piquereau, Jérôme, Mateo, Philippe, Fortin, Dominique, Veksler, Vladimir, Garnier, Anne, Ventura-Clapier, Renée
Format: Article
Language:English
Subjects:
Animals
Aorta
Biology
Biosynthesis
Body weight
Body Weight - drug effects
Cardiology and cardiovascular system
cardiovascular diseases
Circulatory system
Disease Models, Animal
Echocardiography
Endothelium
Endothelium, Vascular - drug effects
Endothelium, Vascular - pathology
Energy metabolism
Energy Metabolism - drug effects
Estrogens
Fatty acids
Heart
Heart - drug effects
Heart - physiopathology
Heart diseases
Heart failure
Heart Failure - etiology
Heart Failure - metabolism
Heart Failure - pathology
Heart Failure - physiopathology
Heart hypertrophy
Hemodynamics
Hemodynamics - drug effects
Human health and pathology
Hypertension
Hypertension - complications
Hypertrophy
Kinases
Life Sciences
Male
Medicine
Metabolism
Metabolites
Mitochondria
Mitochondria - drug effects
Mitochondria - metabolism
Muscle contraction
Nitric oxide
Oxidation
Physiological aspects
Rats
Rats, Inbred Dahl
Resveratrol
Rodents
Salts
Signal Transduction - drug effects
Skeletal muscle
Smooth muscle
Stilbenes - pharmacology
Survival
Survival Analysis
Therapy
Ventricle
Weight reduction
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Heart failure (HF) is characterized by contractile dysfunction associated with altered energy metabolism. This study was aimed at determining whether resveratrol, a polyphenol known to activate energy metabolism, could be beneficial as a metabolic therapy of HF. Survival, ventricular and vascular function as well as cardiac and skeletal muscle energy metabolism were assessed in a hypertensive model of HF, the Dahl salt-sensitive rat fed with a high-salt diet (HS-NT). Resveratrol (18 mg/kg/day; HS-RSV) was given for 8 weeks after hypertension and cardiac hypertrophy were established (which occurred 3 weeks after salt addition). Resveratrol treatment improved survival (64% in HS-RSV versus 15% in HS-NT, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0026391