The prognostic significance of apoptosis-related biological markers in Chinese gastric cancer patients

The prognosis varied among the patients with the same stage, therefore there was a need for new prognostic and predictive factors. The aim of this study was to evaluate the relationship of apoptosis-related biological markers such as p53, bcl-2, bax, and c-myc, and clinicopathological features and t...

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Published in:PloS one 2011-12, Vol.6 (12), p.e29670-e29670
Main Authors: Liu, Xiaowen, Cai, Hong, Huang, Hua, Long, Ziwen, Shi, Yingqiang, Wang, Yanong
Format: Article
Language:English
Subjects:
Analysis
Apoptosis
Bax protein
Bcl-2 protein
Bioindicators
Biological effects
Biological markers
Biology
Biomarkers
Biomarkers, Tumor - blood
c-Myc protein
Cancer
Cancer patients
Care and treatment
Cell cycle
Cell growth
China
Correlation
Female
Females
Gastrectomy
Gastric cancer
Humans
Immunohistochemistry
Lymph nodes
Male
Males
Medical prognosis
Medicine
Metastases
Middle Aged
Multivariate analysis
Myc protein
Oncology
p53 Protein
Patients
Prognosis
Protein expression
Proteins
Proto-Oncogene Proteins c-bcl-2 - metabolism
Proto-Oncogene Proteins c-myc - metabolism
Quality
Stomach cancer
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
Studies
Survival
Tumor proteins
Tumor Suppressor Protein p53 - metabolism
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Summary:The prognosis varied among the patients with the same stage, therefore there was a need for new prognostic and predictive factors. The aim of this study was to evaluate the relationship of apoptosis-related biological markers such as p53, bcl-2, bax, and c-myc, and clinicopathological features and their prognostic value. From 1996 to 2007, 4426 patients had undergone curative D2 gastrectomy for gastric cancer at Fudan University Shanghai Cancer Center. Among 501 patients, the expression levels of p53, bcl-2, bax, and c-myc were examined by immunohistochemistry. The prognostic value of biological markers and the correlation between biological markers and other clinicopathological factors were investigated. There were 339 males and 162 females with a mean age of 57. The percentages of positive expression of p53, bcl-2, bax, and c-myc were 65%, 22%, 43%, and 58%, respectively. There was a strong correlation between p53, bax, and c-myc expression (P=0.00). There was significant association between bcl-2, and bax expression (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0029670