MiR-34a expression has an effect for lower risk of metastasis and associates with expression patterns predicting clinical outcome in breast cancer

MiR-34a acts as a candidate tumour suppressor gene, and its expression is reduced in several cancer types. We aimed to study miR-34a expression in breast cancer and its correlation with tumour characteristics and clinical outcome, and regulatory links with other genes. We analysed miR-34a expression...

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Bibliographic Details
Published in:PloS one 2011-11, Vol.6 (11), p.e26122-e26122
Main Authors: Peurala, Hanna, Greco, Dario, Heikkinen, Tuomas, Kaur, Sippy, Bartkova, Jirina, Jamshidi, Maral, Aittomäki, Kristiina, Heikkilä, Päivi, Bartek, Jiri, Blomqvist, Carl, Bützow, Ralf, Nevanlinna, Heli
Format: Article
Language:English
Subjects:
Apoptosis
Binding sites
Biology
Biomarkers, Tumor - genetics
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Cancer
Cancer metastasis
Cancer research
Carcinoma, Ductal, Breast - genetics
Carcinoma, Ductal, Breast - mortality
Carcinoma, Ductal, Breast - secondary
Carcinoma, Lobular - genetics
Carcinoma, Lobular - mortality
Carcinoma, Lobular - secondary
Cell cycle
Cell growth
Clinical outcomes
Cyclin E
Cyclin E - genetics
Cyclin-dependent kinases
Deoxyribonucleic acid
DNA
DNA binding proteins
DNA damage
DNA methylation
DNA-Binding Proteins - genetics
ErbB-2 protein
Female
Gene expression
Gene Expression Profiling
Genes
Genetic aspects
Genomes
Genomic analysis
Gynecology
Health risks
Histones - genetics
Humans
Kinases
Lung cancer
Medical prognosis
Medical research
Medicine
Metastases
Metastasis
MicroRNAs
MicroRNAs - genetics
Middle Aged
Multivariate analysis
Mutation
Neoplasm Grading
Neoplasm Staging
Obstetrics
Oligonucleotide Array Sequence Analysis
Oncology
p53 Protein
Pathology
Patient outcomes
Prognosis
Proteins
Receptor, ErbB-2 - genetics
Regulatory mechanisms (biology)
Risk
RNA, Messenger - genetics
Survival Rate
Tissue Array Analysis
Transcription (Genetics)
Transcription factors
Transcription Factors - genetics
Tumor proteins
Tumor Suppressor Protein p53 - genetics
Tumors
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Summary:MiR-34a acts as a candidate tumour suppressor gene, and its expression is reduced in several cancer types. We aimed to study miR-34a expression in breast cancer and its correlation with tumour characteristics and clinical outcome, and regulatory links with other genes. We analysed miR-34a expression in 1,172 breast tumours on TMAs. 25% of the tumours showed high, 43% medium and 32% low expression of miR-34a. High miR-34a expression associated with poor prognostic factors for breast cancer: positive nodal status (p = 0.006), high tumour grade (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0026122