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An RGS-containing sorting nexin controls Drosophila lifespan
The pursuit of eternal youth has existed for centuries and recent data indicate that fat-storing tissues control lifespan. In a D. melanogaster fat body insertional mutagenic enhancer trap screen designed to isolate genes that control longevity, we identified a regulator of G protein signaling (RGS)...
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| Published in: | PloS one 2008-05, Vol.3 (5), p.e2152-e2152 |
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| creator | Suh, Jae Myoung Stenesen, Drew Peters, John M Inoue, Akiko Cade, Angela Graff, Jonathan M |
| description | The pursuit of eternal youth has existed for centuries and recent data indicate that fat-storing tissues control lifespan. In a D. melanogaster fat body insertional mutagenic enhancer trap screen designed to isolate genes that control longevity, we identified a regulator of G protein signaling (RGS) domain containing sorting nexin, termed snazarus (sorting nexin lazarus, snz). Flies with insertions into the 5' UTR of snz live up to twice as long as controls. Transgenic expression of UAS-Snz from the snz Gal4 enhancer trap insertion, active in fat metabolic tissues, rescued lifespan extension. Further, the lifespan extension of snz mutants was independent of endosymbiont, e.g., Wolbachia, effects. Notably, old snz mutant flies remain active and fertile indicating that snz mutants have prolonged youthfulness, a goal of aging research. Since mammals have snz-related genes, it is possible that the functions of the snz family may be conserved to humans. |
| doi_str_mv | 10.1371/journal.pone.0002152 |
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In a D. melanogaster fat body insertional mutagenic enhancer trap screen designed to isolate genes that control longevity, we identified a regulator of G protein signaling (RGS) domain containing sorting nexin, termed snazarus (sorting nexin lazarus, snz). Flies with insertions into the 5' UTR of snz live up to twice as long as controls. Transgenic expression of UAS-Snz from the snz Gal4 enhancer trap insertion, active in fat metabolic tissues, rescued lifespan extension. Further, the lifespan extension of snz mutants was independent of endosymbiont, e.g., Wolbachia, effects. Notably, old snz mutant flies remain active and fertile indicating that snz mutants have prolonged youthfulness, a goal of aging research. 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This is an open-access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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In a D. melanogaster fat body insertional mutagenic enhancer trap screen designed to isolate genes that control longevity, we identified a regulator of G protein signaling (RGS) domain containing sorting nexin, termed snazarus (sorting nexin lazarus, snz). Flies with insertions into the 5' UTR of snz live up to twice as long as controls. Transgenic expression of UAS-Snz from the snz Gal4 enhancer trap insertion, active in fat metabolic tissues, rescued lifespan extension. Further, the lifespan extension of snz mutants was independent of endosymbiont, e.g., Wolbachia, effects. Notably, old snz mutant flies remain active and fertile indicating that snz mutants have prolonged youthfulness, a goal of aging research. Since mammals have snz-related genes, it is possible that the functions of the snz family may be conserved to humans.</description><subject>5' Untranslated Regions</subject><subject>Adipocytes</subject><subject>Aging</subject><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>Bacteria</subject><subject>Carrier Proteins - chemistry</subject><subject>Carrier Proteins - physiology</subject><subject>Developmental biology</subject><subject>Developmental Biology/Aging</subject><subject>Developmental Biology/Cell Differentiation</subject><subject>Diabetes and Endocrinology/Obesity</subject><subject>Diabetes and Endocrinology/Type 2 Diabetes</subject><subject>Drosophila</subject><subject>Drosophila - genetics</subject><subject>Drosophila - physiology</subject><subject>Drosophila melanogaster</subject><subject>Fat body</subject><subject>Fat Body - physiology</subject><subject>G proteins</subject><subject>Genes</subject><subject>Genetic engineering</subject><subject>Genetics and Genomics/Gene Discovery</subject><subject>Insects</subject><subject>Insulin resistance</subject><subject>Larva - 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In a D. melanogaster fat body insertional mutagenic enhancer trap screen designed to isolate genes that control longevity, we identified a regulator of G protein signaling (RGS) domain containing sorting nexin, termed snazarus (sorting nexin lazarus, snz). Flies with insertions into the 5' UTR of snz live up to twice as long as controls. Transgenic expression of UAS-Snz from the snz Gal4 enhancer trap insertion, active in fat metabolic tissues, rescued lifespan extension. Further, the lifespan extension of snz mutants was independent of endosymbiont, e.g., Wolbachia, effects. Notably, old snz mutant flies remain active and fertile indicating that snz mutants have prolonged youthfulness, a goal of aging research. Since mammals have snz-related genes, it is possible that the functions of the snz family may be conserved to humans.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>18478054</pmid><doi>10.1371/journal.pone.0002152</doi><tpages>e2152</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 5' Untranslated Regions Adipocytes Aging Animals Animals, Genetically Modified Bacteria Carrier Proteins - chemistry Carrier Proteins - physiology Developmental biology Developmental Biology/Aging Developmental Biology/Cell Differentiation Diabetes and Endocrinology/Obesity Diabetes and Endocrinology/Type 2 Diabetes Drosophila Drosophila - genetics Drosophila - physiology Drosophila melanogaster Fat body Fat Body - physiology G proteins Genes Genetic engineering Genetics and Genomics/Gene Discovery Insects Insulin resistance Larva - physiology Life span Longevity Mammals Metabolic disorders Mutants Mutation Nexin Oligopeptides - chemistry Physiology/Membranes and Sorting Proteins Sorting Nexins Stem cells Tissues Transcription factors Vesicular Transport Proteins - chemistry Vesicular Transport Proteins - physiology Youth |
| title | An RGS-containing sorting nexin controls Drosophila lifespan |
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