Concordant gene expression in leukemia cells and normal leukocytes is associated with germline cis-SNPs

The degree to which gene expression covaries between different primary tissues within an individual is not well defined. We hypothesized that expression that is concordant across tissues is more likely influenced by genetic variability than gene expression which is discordant between tissues. We qua...

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Bibliographic Details
Published in:PloS one 2008-05, Vol.3 (5), p.e2144-e2144
Main Authors: French, Deborah, Yang, Wenjian, Hamilton, Leo H, Neale, Geoffrey, Fan, Yiping, Downing, James R, Cox, Nancy J, Pui, Ching-Hon, Evans, William E, Relling, Mary V
Format: Article
Language:English
Subjects:
Acids
Acute lymphoblastic leukemia
Bioinformatics
Cancer genetics
Cancer therapies
Child
Children & youth
Cytotoxicity
Gene expression
Gene Expression Profiling
Gene Expression Regulation, Leukemic
Genes
Genetic aspects
Genetic variability
Genetics and Genomics/Bioinformatics
Genetics and Genomics/Cancer Genetics
Genetics and Genomics/Gene Expression
Genomes
Genotype
Genotypes
Germ-Line Mutation
Glyceraldehyde-3-phosphate dehydrogenase
Hematology/Acute Lymphoblastic Leukemia
Humans
Leukemia
Leukocytes
Leukocytes - metabolism
Lymphatic leukemia
Medical diagnosis
Metabolism
Patients
Pharmaceutical sciences
Physiological aspects
Pilot projects
Polymorphism, Single Nucleotide
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Studies
Tissues
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Summary:The degree to which gene expression covaries between different primary tissues within an individual is not well defined. We hypothesized that expression that is concordant across tissues is more likely influenced by genetic variability than gene expression which is discordant between tissues. We quantified expression of 11,873 genes in paired samples of primary leukemia cells and normal leukocytes from 92 patients with acute lymphoblastic leukemia (ALL). Genetic variation at >500,000 single nucleotide polymorphisms (SNPs) was also assessed. The expression of only 176/11,783 (1.5%) genes was correlated (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0002144