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Allogeneic lymphocytes persist and traffic in feral MHC-matched mauritian cynomolgus macaques
Thus far, live attenuated SIV has been the most successful method for vaccinating macaques against pathogenic SIV challenge; however, it is not clear what mechanisms are responsible for this protection. Adoptive transfer studies in mice have been integral to understanding live attenuated vaccine pro...
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| Published in: | PloS one 2008-06, Vol.3 (6), p.e2384-e2384 |
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| creator | Greene, Justin M Burwitz, Benjamin J Blasky, Alex J Mattila, Teresa L Hong, Jung Joo Rakasz, Eva G Wiseman, Roger W Hasenkrug, Kim J Skinner, Pamela J O'Connor, Shelby L O'Connor, David H |
| description | Thus far, live attenuated SIV has been the most successful method for vaccinating macaques against pathogenic SIV challenge; however, it is not clear what mechanisms are responsible for this protection. Adoptive transfer studies in mice have been integral to understanding live attenuated vaccine protection in models like Friend virus. Previous adoptive transfers in primates have failed as transferred cells are typically cleared within hours after transfer.
Here we describe adoptive transfer studies in Mauritian origin cynomolgus macaques (MCM), a non-human primate model with limited MHC diversity. Cells transferred between unrelated MHC-matched macaques persist for at least fourteen days but are rejected within 36 hours in MHC-mismatched macaques. Cells trafficked from the blood to peripheral lymphoid tissues within 12 hours of transfer.
MHC-matched MCM provide the first viable primate model for adoptive transfer studies. Because macaques infected with SIV are the best model for HIV/AIDS pathogenesis, we can now directly study the correlates of protective immune responses to AIDS viruses. For example, plasma viral loads following pathogenic SIV challenge are reduced by several orders of magnitude in macaques previously immunized with attenuated SIV. Adoptive transfer of lymphocyte subpopulations from vaccinated donors into SIV-naïve animals may define the immune mechanisms responsible for protection and guide future vaccine development. |
| doi_str_mv | 10.1371/journal.pone.0002384 |
| format | article |
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Here we describe adoptive transfer studies in Mauritian origin cynomolgus macaques (MCM), a non-human primate model with limited MHC diversity. Cells transferred between unrelated MHC-matched macaques persist for at least fourteen days but are rejected within 36 hours in MHC-mismatched macaques. Cells trafficked from the blood to peripheral lymphoid tissues within 12 hours of transfer.
MHC-matched MCM provide the first viable primate model for adoptive transfer studies. Because macaques infected with SIV are the best model for HIV/AIDS pathogenesis, we can now directly study the correlates of protective immune responses to AIDS viruses. For example, plasma viral loads following pathogenic SIV challenge are reduced by several orders of magnitude in macaques previously immunized with attenuated SIV. Adoptive transfer of lymphocyte subpopulations from vaccinated donors into SIV-naïve animals may define the immune mechanisms responsible for protection and guide future vaccine development.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0002384</identifier><identifier>PMID: 18545705</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acquired immune deficiency syndrome ; Adoptive Transfer ; AIDS ; AIDS vaccines ; Analysis ; Animal models ; Animal tissues ; Animals ; Animals, Wild ; Attenuation ; B cells ; Base Sequence ; CD8-Positive T-Lymphocytes - immunology ; Correlation analysis ; Cynomolgus ; DNA Primers ; Haplotypes ; HIV ; Human immunodeficiency virus ; Immune response ; Immunization ; Immunology ; Immunology/Immune Response ; Immunology/Immunity to Infections ; Infectious Diseases/HIV Infection and AIDS ; Laboratories ; Lymphocytes ; Lymphoid tissue ; Macaca ; Macaca fascicularis ; Major Histocompatibility Complex ; Medical research ; Microsatellite Repeats - genetics ; Monkeys & apes ; Pathogenesis ; Primates ; Protection and preservation ; Simian immunodeficiency virus ; Simian Immunodeficiency Virus - immunology ; Subpopulations ; Traffic models ; Vaccination ; Vaccine development ; Vaccines ; Virology/Animal Models of Infection ; Virology/Host Antiviral Responses ; Virology/Immunodeficiency Viruses ; Virology/Vaccines ; Viruses</subject><ispartof>PloS one, 2008-06, Vol.3 (6), p.e2384-e2384</ispartof><rights>COPYRIGHT 2008 Public Library of Science</rights><rights>This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c759t-eeddf2268074b6e7724b5e3c20f1db1aa1da9c30576f8e2228486fdef4d50a443</citedby><cites>FETCH-LOGICAL-c759t-eeddf2268074b6e7724b5e3c20f1db1aa1da9c30576f8e2228486fdef4d50a443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1312288861/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1312288861?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18545705$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Unutmaz, Derya</contributor><creatorcontrib>Greene, Justin M</creatorcontrib><creatorcontrib>Burwitz, Benjamin J</creatorcontrib><creatorcontrib>Blasky, Alex J</creatorcontrib><creatorcontrib>Mattila, Teresa L</creatorcontrib><creatorcontrib>Hong, Jung Joo</creatorcontrib><creatorcontrib>Rakasz, Eva G</creatorcontrib><creatorcontrib>Wiseman, Roger W</creatorcontrib><creatorcontrib>Hasenkrug, Kim J</creatorcontrib><creatorcontrib>Skinner, Pamela J</creatorcontrib><creatorcontrib>O'Connor, Shelby L</creatorcontrib><creatorcontrib>O'Connor, David H</creatorcontrib><title>Allogeneic lymphocytes persist and traffic in feral MHC-matched mauritian cynomolgus macaques</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Thus far, live attenuated SIV has been the most successful method for vaccinating macaques against pathogenic SIV challenge; however, it is not clear what mechanisms are responsible for this protection. Adoptive transfer studies in mice have been integral to understanding live attenuated vaccine protection in models like Friend virus. Previous adoptive transfers in primates have failed as transferred cells are typically cleared within hours after transfer.
Here we describe adoptive transfer studies in Mauritian origin cynomolgus macaques (MCM), a non-human primate model with limited MHC diversity. Cells transferred between unrelated MHC-matched macaques persist for at least fourteen days but are rejected within 36 hours in MHC-mismatched macaques. Cells trafficked from the blood to peripheral lymphoid tissues within 12 hours of transfer.
MHC-matched MCM provide the first viable primate model for adoptive transfer studies. Because macaques infected with SIV are the best model for HIV/AIDS pathogenesis, we can now directly study the correlates of protective immune responses to AIDS viruses. For example, plasma viral loads following pathogenic SIV challenge are reduced by several orders of magnitude in macaques previously immunized with attenuated SIV. 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Adoptive transfer studies in mice have been integral to understanding live attenuated vaccine protection in models like Friend virus. Previous adoptive transfers in primates have failed as transferred cells are typically cleared within hours after transfer.
Here we describe adoptive transfer studies in Mauritian origin cynomolgus macaques (MCM), a non-human primate model with limited MHC diversity. Cells transferred between unrelated MHC-matched macaques persist for at least fourteen days but are rejected within 36 hours in MHC-mismatched macaques. Cells trafficked from the blood to peripheral lymphoid tissues within 12 hours of transfer.
MHC-matched MCM provide the first viable primate model for adoptive transfer studies. Because macaques infected with SIV are the best model for HIV/AIDS pathogenesis, we can now directly study the correlates of protective immune responses to AIDS viruses. For example, plasma viral loads following pathogenic SIV challenge are reduced by several orders of magnitude in macaques previously immunized with attenuated SIV. Adoptive transfer of lymphocyte subpopulations from vaccinated donors into SIV-naïve animals may define the immune mechanisms responsible for protection and guide future vaccine development.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>18545705</pmid><doi>10.1371/journal.pone.0002384</doi><tpages>e2384</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2008-06, Vol.3 (6), p.e2384-e2384 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| subjects | Acquired immune deficiency syndrome Adoptive Transfer AIDS AIDS vaccines Analysis Animal models Animal tissues Animals Animals, Wild Attenuation B cells Base Sequence CD8-Positive T-Lymphocytes - immunology Correlation analysis Cynomolgus DNA Primers Haplotypes HIV Human immunodeficiency virus Immune response Immunization Immunology Immunology/Immune Response Immunology/Immunity to Infections Infectious Diseases/HIV Infection and AIDS Laboratories Lymphocytes Lymphoid tissue Macaca Macaca fascicularis Major Histocompatibility Complex Medical research Microsatellite Repeats - genetics Monkeys & apes Pathogenesis Primates Protection and preservation Simian immunodeficiency virus Simian Immunodeficiency Virus - immunology Subpopulations Traffic models Vaccination Vaccine development Vaccines Virology/Animal Models of Infection Virology/Host Antiviral Responses Virology/Immunodeficiency Viruses Virology/Vaccines Viruses |
| title | Allogeneic lymphocytes persist and traffic in feral MHC-matched mauritian cynomolgus macaques |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T14%3A22%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Allogeneic%20lymphocytes%20persist%20and%20traffic%20in%20feral%20MHC-matched%20mauritian%20cynomolgus%20macaques&rft.jtitle=PloS%20one&rft.au=Greene,%20Justin%20M&rft.date=2008-06-11&rft.volume=3&rft.issue=6&rft.spage=e2384&rft.epage=e2384&rft.pages=e2384-e2384&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0002384&rft_dat=%3Cgale_plos_%3EA472647865%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c759t-eeddf2268074b6e7724b5e3c20f1db1aa1da9c30576f8e2228486fdef4d50a443%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1312288861&rft_id=info:pmid/18545705&rft_galeid=A472647865&rfr_iscdi=true |