Administration of M. leprae Hsp65 interferes with the murine lupus progression

The heat shock protein [Hsp] family guides several steps during protein synthesis, are abundant in prokaryotic and eukaryotic cells, and are highly conserved during evolution. The Hsp60 family is involved in assembly and transport of proteins, and is expressed at very high levels during autoimmunity...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2008-08, Vol.3 (8), p.e3025
Main Authors: Marengo, Eliana B, de Moraes, Luciana V, Faria, Marcella, Fernandes, Beatriz L, Carvalho, Luciana V, Tambourgi, Denise V, Rizzo, Luiz V, Portaro, Fernanda C V, Camargo, Antônio Carlos M, Sant'anna, Osvaldo A
Format: Article
Language:English
Subjects:
Amino acids
Analysis
Animal models
Animals
Anti-DNA antibodies
Antibodies
Antibody Formation
Antigens
Apoptosis
Arthritis
Autoimmune diseases
Autoimmunity
Bacterial Proteins - therapeutic use
Biochemistry
Biocompatibility
Biomedical research
Chaperonin 60
Chaperonins - therapeutic use
Chronic conditions
Cytokines
Deoxyribonucleic acid
Disease Models, Animal
Disease Progression
DNA
DNA - immunology
Dose-Response Relationship, Drug
Environmental factors
Environmental impact
Evolutionary Biology
Gene mutation
Glomerulonephritis - etiology
Glomerulonephritis - physiopathology
Glycoproteins
Heat shock proteins
Hsp60 protein
Hsp65 protein
Immunogenicity
Immunoglobulin G
Immunoglobulins
Immunology
Immunology/Autoimmunity
Immunology/Immune Response
Immunology/Immunomodulation
Laboratories
Leprosy
Life span
Lupus
Lupus Erythematosus, Systemic - classification
Lupus Erythematosus, Systemic - physiopathology
Lupus Erythematosus, Systemic - prevention & control
Macrophages
Mice
Mycobacterium leprae
Pathogenesis
Pharmacology
Protein biosynthesis
Protein synthesis
Proteins
Rodents
Systemic lupus erythematosus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The heat shock protein [Hsp] family guides several steps during protein synthesis, are abundant in prokaryotic and eukaryotic cells, and are highly conserved during evolution. The Hsp60 family is involved in assembly and transport of proteins, and is expressed at very high levels during autoimmunity or autoinflammatory phenomena. Here, the pathophysiological role of the wild type [WT] and the point mutated K(409)A recombinant Hsp65 of M. leprae in an animal model of Systemic Lupus Erythematosus [SLE] was evaluated in vivo using the genetically homogeneous [NZBxNZW]F(1) mice. Anti-DNA and anti-Hsp65 antibodies responsiveness was individually measured during the animal's life span, and the mean survival time [MST] was determined. The treatment with WT abbreviates the MST in 46%, when compared to non-treated mice [p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0003025