Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma

• Published in: PloS one 2008-07, Vol.3 (7), p.e2816-e2816
• Main Authors: Skibola, Christine F, Bracci, Paige M, Halperin, Eran, Nieters, Alexandra, Hubbard, Alan, Paynter, Randi A, Skibola, Danica R, Agana, Luz, Becker, Nikolaus, Tressler, Patrick, Forrest, Matthew S, Sankararaman, Sriram, Conde, Lucia, Holly, Elizabeth A, Smith, Martyn T
• Format: Article
• Language: English
• Subjects: Acids; Apoptosis; Ascorbic acid; Ascorbic Acid - genetics; Ascorbic Acid - metabolism; Biomarkers; Cancer; Cancer therapies; Case-Control Studies; Cholesterol; Computer science; Confidence intervals; Consortia; Disease susceptibility; Ecological risk assessment; Energy balance; Energy metabolism; Environment; Environmental health; Environmental risk; Epidemiology; Estrogen; Estrogen Receptor alpha - genetics; Estrogen Receptor alpha - metabolism; Estrogen receptors; Estrogens; Female; Folic acid; Gelatinase B; Gene families; Gene Frequency; Genes; Genetic aspects; Genetic Predisposition to Disease; Genetics and Genomics; Genetics and Genomics/Cancer Genetics; Genetics and Genomics/Disease Models; Haplotypes; Health sciences; Hematology; Hematology/Lymphomas and Chronic Lymphoblastic Leukemia; HIV; Human immunodeficiency virus; Humans; Immune response; Leukemia; Lipid metabolism; Lymphoma; Lymphoma, Non-Hodgkin - diagnosis; Lymphoma, Non-Hodgkin - genetics; Lymphomas; Male; Matrix metalloproteinase; Matrix metalloproteinases; Matrix Metalloproteinases - genetics; Matrix Metalloproteinases - metabolism; Medical research; Metabolism; Metalloproteinase; Models, Genetic; Non-Hodgkin's lymphomas; Oncology, Experimental; Oxidative metabolism; Oxidative stress; Pancreatic cancer; Pathogenesis; Phenols; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Population; Population (statistical); Population studies; Public health; Risk analysis; Risk Factors; Risk reduction; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Statins; Statistical analysis; Steroidogenesis; Stromelysin 1; Studies; Tagging; Tumors; Vitamin C; Vitamin D
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0002816

Non-Hodgkin lymphoma (NHL) is the fifth most common cancer in the U.S. and few causes have been identified. Genetic association studies may help identify environmental risk factors and enhance our understanding of disease mechanisms. 768 coding and haplotype tagging SNPs in 146 genes were examined using Illumina GoldenGate technology in a large population-based case-control study of NHL in the San Francisco Bay Area (1,292 cases 1,375 controls are included here). Statistical analyses were restricted to HIV- participants of white non-Hispanic origin. Genes involved in steroidogenesis, immune function, cell signaling, sunlight exposure, xenobiotic metabolism/oxidative stress, energy balance, and uptake and metabolism of cholesterol, folate and vitamin C were investigated. Sixteen SNPs in eight pathways and nine haplotypes were associated with NHL after correction for multiple testing at the adjusted q