Cholinergic neuromodulation changes phase response curve shape and type in cortical pyramidal neurons

Spike generation in cortical neurons depends on the interplay between diverse intrinsic conductances. The phase response curve (PRC) is a measure of the spike time shift caused by perturbations of the membrane potential as a function of the phase of the spike cycle of a neuron. Near the rheobase, pu...

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Bibliographic Details
Published in:PloS one 2008-12, Vol.3 (12), p.e3947-e3947
Main Authors: Stiefel, Klaus M, Gutkin, Boris S, Sejnowski, Terrence J
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Action Potentials - physiology
Analysis
Animals
Bifurcations
Brain slice preparation
Carbachol - pharmacology
Choline - pharmacology
Mathematics/Nonlinear Dynamics
Membrane potential
Mice
Neurogenesis
Neuromodulation
Neurons
Neuroscience
Neuroscience/Neuronal and Glial Cell Biology
Neuroscience/Theoretical Neuroscience
Neurosciences
Phase transitions
Potassium
Potassium channels (voltage-gated)
Potassium currents
Pyramidal cells
Pyramidal Cells - drug effects
Pyramidal Cells - physiology
Rodents
Studies
Visual Cortex - cytology
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Summary:Spike generation in cortical neurons depends on the interplay between diverse intrinsic conductances. The phase response curve (PRC) is a measure of the spike time shift caused by perturbations of the membrane potential as a function of the phase of the spike cycle of a neuron. Near the rheobase, purely positive (type I) phase-response curves are associated with an onset of repetitive firing through a saddle-node bifurcation, whereas biphasic (type II) phase-response curves point towards a transition based on a Hopf-Andronov bifurcation. In recordings from layer 2/3 pyramidal neurons in cortical slices, cholinergic action, consistent with down-regulation of slow voltage-dependent potassium currents such as the M-current, switched the PRC from type II to type I. This is the first report showing that cholinergic neuromodulation may cause a qualitative switch in the PRCs type implying a change in the fundamental dynamical mechanism of spike generation.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0003947