Connectivity of the primate superior colliculus mapped by concurrent microstimulation and event-related FMRI

Neuroanatomical studies investigating the connectivity of brain areas have heretofore employed procedures in which chemical or viral tracers are injected into an area of interest, and connected areas are subsequently identified using histological techniques. Such experiments require the sacrifice of...

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Bibliographic Details
Published in:PloS one 2008-12, Vol.3 (12), p.e3928-e3928
Main Authors: Field, Courtney B, Johnston, Kevin, Gati, Joseph S, Menon, Ravi S, Everling, Stefan
Format: Article
Language:English
Subjects:
Anatomy
Animal experimentation
Animals
Brain
Brain architecture
Brain mapping
Brain Mapping - methods
Brain research
Colliculus
Cortex
Electric Stimulation
Functional magnetic resonance imaging
Magnetic Resonance Imaging
Mapping
Medical imaging
Microelectrodes
Neural networks
Neurons
Neuroscience/Motor Systems
Neuroscience/Sensory Systems
NMR
Nuclear magnetic resonance
Oxygen - blood
Oxygenation
Parkinson's disease
Parkinsons disease
Physiology
Primates
Primates - physiology
Radiology and Medical Imaging/Magnetic Resonance Imaging
Research methodology
Smooth muscle
Studies
Superior Colliculi - physiology
Superior colliculus
Time Factors
Tracers
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Summary:Neuroanatomical studies investigating the connectivity of brain areas have heretofore employed procedures in which chemical or viral tracers are injected into an area of interest, and connected areas are subsequently identified using histological techniques. Such experiments require the sacrifice of the animals and do not allow for subsequent electrophysiological studies in the same subjects, rendering a direct investigation of the functional properties of anatomically identified areas impossible. Here, we used a combination of microstimulation and fMRI in an anesthetized monkey preparation to study the connectivity of the superior colliculus (SC). Microstimulation of the SC resulted in changes in the blood oxygenation level-dependent (BOLD) signals in the SC and in several cortical and subcortical areas consistent with the known connectivity of the SC in primates. These findings demonstrates that the concurrent use of microstimulation and fMRI can be used to identify brain networks for further electrophysiological or fMRI investigation.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0003928