Immunoinformatics comes of age

With the burgeoning immunological data in the scientific literature, scientists must increasingly rely on Internet resources to inform and enhance their work. Here we provide a brief overview of the adaptive immune response and summaries of immunoinformatics resources, emphasizing those with Web int...

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Bibliographic Details
Published in:PLoS computational biology 2006-06, Vol.2 (6), p.e71-e71
Main Authors: Korber, Bette, LaBute, Montiago, Yusim, Karina
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Bacterial cell walls
Bioinformatics - Computational Biology
Computational Biology - trends
Databases, Factual
Epitopes, B-Lymphocyte - chemistry
Epitopes, B-Lymphocyte - immunology
Epitopes, T-Lymphocyte - chemistry
Epitopes, T-Lymphocyte - immunology
Genetic aspects
HIV - AIDS
Homo (Human)
Humans
Immune response
Immune system
Immunity - immunology
Immunology
Infectious Diseases
Mammals
Peptides
Physiological aspects
Proteins
Review
T cell receptors
Vaccines
Viruses
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Summary:With the burgeoning immunological data in the scientific literature, scientists must increasingly rely on Internet resources to inform and enhance their work. Here we provide a brief overview of the adaptive immune response and summaries of immunoinformatics resources, emphasizing those with Web interfaces. These resources include searchable databases of epitopes and immune-related molecules, and analysis tools for T cell and B cell epitope prediction, vaccine design, and protein structure comparisons. There is an agreeable synergy between the growing collections in immune-related databases and the growing sophistication of analysis software; the databases provide the foundation for developing predictive computational tools, which in turn enable more rapid identification of immune responses to populate the databases. Collectively, these resources contribute to improved understanding of immune responses and escape, and evolution of pathogens under immune pressure. The public health implications are vast, including designing vaccines, understanding autoimmune diseases, and defining the correlates of immune protection.
ISSN:1553-7358
1553-734X
1553-7358
DOI:10.1371/journal.pcbi.0020071