Modelling vesicular release at hippocampal synapses

We study local calcium dynamics leading to a vesicle fusion in a stochastic, and spatially explicit, biophysical model of the CA3-CA1 presynaptic bouton. The kinetic model for vesicle release has two calcium sensors, a sensor for fast synchronous release that lasts a few tens of milliseconds and a s...

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Bibliographic Details
Published in:PLoS computational biology 2010-11, Vol.6 (11), p.e1000983-e1000983
Main Authors: Nadkarni, Suhita, Bartol, Thomas M, Sejnowski, Terrence J, Levine, Herbert
Format: Article
Language:English
Subjects:
Biophysics/Biomacromolecule-Ligand Interactions
Biophysics/Cell Signaling and Trafficking Structures
Biophysics/Theory and Simulation
CA1 Region, Hippocampal
CA3 Region, Hippocampal
Calcium
Calcium - metabolism
Cell Biology/Cell Signaling
Computational biology
Computational Biology/Computational Neuroscience
Computational Biology/Signaling Networks
Computer Simulation
Diffusion
Exocytosis - physiology
Experiments
Hippocampus (Brain)
Models, Neurological
Monte Carlo Method
Neural transmission
Neuronal Plasticity - physiology
Neuroscience/Neuronal and Glial Cell Biology
Neuroscience/Neuronal Signaling Mechanisms
Neuroscience/Theoretical Neuroscience
Physiological aspects
Proteins
Reproducibility of Results
Stochastic Processes
Studies
Synapses - chemistry
Synaptic Transmission - physiology
Synaptic Vesicles - chemistry
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Summary:We study local calcium dynamics leading to a vesicle fusion in a stochastic, and spatially explicit, biophysical model of the CA3-CA1 presynaptic bouton. The kinetic model for vesicle release has two calcium sensors, a sensor for fast synchronous release that lasts a few tens of milliseconds and a separate sensor for slow asynchronous release that lasts a few hundred milliseconds. A wide range of data can be accounted for consistently only when a refractory period lasting a few milliseconds between releases is included. The inclusion of a second sensor for asynchronous release with a slow unbinding site, and thereby a long memory, affects short-term plasticity by facilitating release. Our simulations also reveal a third time scale of vesicle release that is correlated with the stimulus and is distinct from the fast and the slow releases. In these detailed Monte Carlo simulations all three time scales of vesicle release are insensitive to the spatial details of the synaptic ultrastructure. Furthermore, our simulations allow us to identify features of synaptic transmission that are universal and those that are modulated by structure.
ISSN:1553-7358
1553-734X
1553-7358
DOI:10.1371/journal.pcbi.1000983