Condensin II promotes the formation of chromosome territories by inducing axial compaction of polyploid interphase chromosomes

The eukaryotic nucleus is both spatially and functionally partitioned. This organization contributes to the maintenance, expression, and transmission of genetic information. Though our ability to probe the physical structure of the genome within the nucleus has improved substantially in recent years...

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Bibliographic Details
Published in:PLoS genetics 2012-08, Vol.8 (8), p.e1002873-e1002873
Main Authors: Bauer, Christopher R, Hartl, Tom A, Bosco, Giovanni
Format: Article
Language:English
Subjects:
Adenosine Triphosphatases - genetics
Animal genetics
Animals
Biology
Cell Compartmentation - genetics
Cell Nucleus - genetics
Cell Nucleus - metabolism
Centromere - genetics
Chromosomal Proteins, Non-Histone - genetics
Chromosomes
DNA repair
DNA-Binding Proteins - genetics
Drosophila
Drosophila melanogaster
Drosophila melanogaster - genetics
Drosophila Proteins - genetics
Gene expression
Genetic aspects
Genomes
Genomics
Heterochromatin - genetics
Interphase - genetics
Mitosis
Multiprotein Complexes - genetics
Physiological aspects
Polyploidy
Polytene Chromosomes - genetics
Polytene Chromosomes - metabolism
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Summary:The eukaryotic nucleus is both spatially and functionally partitioned. This organization contributes to the maintenance, expression, and transmission of genetic information. Though our ability to probe the physical structure of the genome within the nucleus has improved substantially in recent years, relatively little is known about the factors that regulate its organization or the mechanisms through which specific organizational states are achieved. Here, we show that Drosophila melanogaster Condensin II induces axial compaction of interphase chromosomes, globally disrupts interchromosomal interactions, and promotes the dispersal of peri-centric heterochromatin. These Condensin II activities compartmentalize the nucleus into discrete chromosome territories and indicate commonalities in the mechanisms that regulate the spatial structure of the genome during mitosis and interphase.
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.1002873