GWAS of diabetic nephropathy: is the GENIE out of the bottle?

[...]the DN definition essentially mixes two traits, each with distinct underlying pathomechanisms: ESRD as the extreme form of reduced kidney function (glomerular filtration rate, GFR), and macroalbuminuria reflecting severe glomerular filtration barrier dysfunction. Since these two traits have dis...

Full description

Saved in:
Bibliographic Details
Published in:PLoS genetics 2012-09, Vol.8 (9), p.e1002989-e1002989
Main Authors: Böger, Carsten A, Sedor, John R
Format: Article
Language:English
Subjects:
Biology
Care and treatment
Cell culture
Development and progression
Diabetes
Diabetes Mellitus, Type 1 - genetics
Diabetic nephropathies
Diabetic Nephropathies - genetics
Disease
ErbB Receptors - genetics
Gene loci
Genetic aspects
Genomes
Genomics
Health risk assessment
Histology
Humans
Kidney diseases
Kidney Failure, Chronic
Medicine
Mortality
Nuclear Proteins - genetics
Pathogenesis
Patients
Physiological aspects
Receptor, ErbB-4
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[...]the DN definition essentially mixes two traits, each with distinct underlying pathomechanisms: ESRD as the extreme form of reduced kidney function (glomerular filtration rate, GFR), and macroalbuminuria reflecting severe glomerular filtration barrier dysfunction. Since these two traits have distinct genetic underpinnings [11]-[16], the authors refined their DN case definition to include only diabetic ESRD patients, which were contrasted with all other diabetic individuals regardless of albumin excretion level. [...]additional meta-analyses of T1D and T2D DN cohorts with larger sample sizes, application of sequencing technologies, and use of more precise DN phenotypes from longitudinal studies should further define the genetic architecture of this most common cause of chronic kidney disease.
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.1002989