A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans

Several genetic variants associated with platelet count and mean platelet volume (MPV) were recently reported in people of European ancestry. In this meta-analysis of 7 genome-wide association studies (GWAS) enrolling African Americans, our aim was to identify novel genetic variants associated with...

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Bibliographic Details
Published in:PLoS genetics 2012-03, Vol.8 (3), p.e1002491
Main Authors: Qayyum, Rehan, Snively, Beverly M, Ziv, Elad, Nalls, Michael A, Liu, Yongmei, Tang, Weihong, Yanek, Lisa R, Lange, Leslie, Evans, Michele K, Ganesh, Santhi, Austin, Melissa A, Lettre, Guillaume, Becker, Diane M, Zonderman, Alan B, Singleton, Andrew B, Harris, Tamara B, Mohler, Emile R, Logsdon, Benjamin A, Kooperberg, Charles, Folsom, Aaron R, Wilson, James G, Becker, Lewis C, Reiner, Alexander P
Format: Article
Language:English
Subjects:
Adult
African Americans
Aged
Aging
Biology
Black or African American - genetics
Blood platelets
Blood Platelets - metabolism
Female
Genetic aspects
Genome-Wide Association Study
Genotype
Hispanic Americans
Humans
Male
Medical treatment
Medicine
Meta-analysis
Middle Aged
Physiological aspects
Platelet Aggregation - genetics
Platelet Count
Polymorphism, Single Nucleotide
Population genetics
Studies
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Summary:Several genetic variants associated with platelet count and mean platelet volume (MPV) were recently reported in people of European ancestry. In this meta-analysis of 7 genome-wide association studies (GWAS) enrolling African Americans, our aim was to identify novel genetic variants associated with platelet count and MPV. For all cohorts, GWAS analysis was performed using additive models after adjusting for age, sex, and population stratification. For both platelet phenotypes, meta-analyses were conducted using inverse-variance weighted fixed-effect models. Platelet aggregation assays in whole blood were performed in the participants of the GeneSTAR cohort. Genetic variants in ten independent regions were associated with platelet count (N = 16,388) with p
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.1002491