Found: the elusive ANTAR transcription antiterminator

Strikingly, both the P1 and P2 loops contain the critical residues A1 and G4, identified as essential for NasR-mediated antitermination [16]. [...]the distal stem of P2 overlaps part of the terminator proximal stem [6], [20], and thereby forms an antiterminator structure (Figure 1B). [...]Ramesh et...

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Bibliographic Details
Published in:PLoS genetics 2012-06, Vol.8 (6), p.e1002773-e1002773
Main Authors: Stewart, Valley, van Tilbeurgh, Herman
Format: Article
Language:English
Subjects:
Bacteria - genetics
Bacterial Proteins - genetics
Binding sites
Biology
Gene expression
Genetic transcription
Inverted Repeat Sequences - genetics
Kinases
Leadership
Nitrates
Phosphorylation
Physiological aspects
Protein Structure, Tertiary
Proteins
RNA polymerase
RNA polymerases
RNA-Binding Proteins - genetics
RNA-Binding Proteins - metabolism
Signal transduction
Terminator Regions, Genetic - genetics
Transcription, Genetic
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Summary:Strikingly, both the P1 and P2 loops contain the critical residues A1 and G4, identified as essential for NasR-mediated antitermination [16]. [...]the distal stem of P2 overlaps part of the terminator proximal stem [6], [20], and thereby forms an antiterminator structure (Figure 1B). [...]Ramesh et al. conducted bioinformatic analyses to identify ANTAR target leaders in bacterial genomes. Together, these results provide concrete hypotheses for the structure and function of both ANTAR domain proteins and their leader RNA targets. [...]the association of many ANTAR regulators with aspects of nitrogen metabolism provokes intriguing questions about their physiology and evolution.
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.1002773