Identification of new genetic risk variants for type 2 diabetes

Although more than 20 genetic susceptibility loci have been reported for type 2 diabetes (T2D), most reported variants have small to moderate effects and account for only a small proportion of the heritability of T2D, suggesting that the majority of inter-person genetic variation in this disease rem...

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Bibliographic Details
Published in:PLoS genetics 2010-09, Vol.6 (9), p.e1001127-e1001127
Main Authors: Shu, Xiao Ou, Long, Jirong, Cai, Qiuyin, Qi, Lu, Xiang, Yong-Bing, Cho, Yoon Shin, Tai, E Shyong, Li, Xiangyang, Lin, Xu, Chow, Wong-Ho, Go, Min Jin, Seielstad, Mark, Bao, Wei, Li, Huaixing, Cornelis, Marilyn C, Yu, Kai, Wen, Wanqing, Shi, Jiajun, Han, Bok-Ghee, Sim, Xue Ling, Liu, Liegang, Qi, Qibin, Kim, Hyung-Lae, Ng, Daniel P K, Lee, Jong-Young, Kim, Young Jin, Li, Chun, Gao, Yu-Tang, Zheng, Wei, Hu, Frank B
Format: Article
Language:English
Subjects:
Alleles
Allelomorphism
Asian Continental Ancestry Group - genetics
China
Chromosomes, Human - genetics
Diabetes
Diabetes Mellitus, Type 2 - genetics
DNA replication
Female
Genealogy
Genetic Predisposition to Disease
Genetics
Genetics and Genomics
Genetics and Genomics/Gene Discovery
Genetics and Genomics/Genetics of Disease
Genomes
Health risk assessment
Humans
Identification and classification
Insulin resistance
Male
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide - genetics
Risk Factors
Single nucleotide polymorphisms
Studies
Type 2 diabetes
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Summary:Although more than 20 genetic susceptibility loci have been reported for type 2 diabetes (T2D), most reported variants have small to moderate effects and account for only a small proportion of the heritability of T2D, suggesting that the majority of inter-person genetic variation in this disease remains to be determined. We conducted a multistage, genome-wide association study (GWAS) within the Asian Consortium of Diabetes to search for T2D susceptibility markers. From 590,887 SNPs genotyped in 1,019 T2D cases and 1,710 controls selected from Chinese women in Shanghai, we selected the top 2,100 SNPs that were not in linkage disequilibrium (r(2)
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.1001127