A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease

Crohn's disease (CD) and celiac disease (CelD) are chronic intestinal inflammatory diseases, involving genetic and environmental factors in their pathogenesis. The two diseases can co-occur within families, and studies suggest that CelD patients have a higher risk to develop CD than the general...

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Published in:PLoS genetics 2011-01, Vol.7 (1), p.e1001283-e1001283
Main Authors: Festen, Eleonora A M, Goyette, Philippe, Green, Todd, Boucher, Gabrielle, Beauchamp, Claudine, Trynka, Gosia, Dubois, Patrick C, Lagacé, Caroline, Stokkers, Pieter C F, Hommes, Daan W, Barisani, Donatella, Palmieri, Orazio, Annese, Vito, van Heel, David A, Weersma, Rinse K, Daly, Mark J, Wijmenga, Cisca, Rioux, John D
Format: Article
Language:English
Subjects:
Celiac disease
Celiac Disease - genetics
Crohn Disease - genetics
Crohn's disease
Data Interpretation, Statistical
Diet
Gastroenterology and Hepatology/Inflammatory Bowel Disease
Gastroenterology and Hepatology/Small Intestine
Genetic aspects
Genetic Predisposition to Disease
Genetic susceptibility
Genetics
Genetics and Genomics/Complex Traits
Genetics and Genomics/Gene Discovery
Genetics and Genomics/Genetics of Disease
Genome-Wide Association Study
Genomes
GTPase-Activating Proteins - genetics
Humans
Hydro-Lyases - genetics
Interferon gamma
Interleukin-18 Receptor beta Subunit - genetics
Interleukins
Medical research
Meta-analysis
Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics
Risk Factors
Small intestine
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Summary:Crohn's disease (CD) and celiac disease (CelD) are chronic intestinal inflammatory diseases, involving genetic and environmental factors in their pathogenesis. The two diseases can co-occur within families, and studies suggest that CelD patients have a higher risk to develop CD than the general population. These observations suggest that CD and CelD may share common genetic risk loci. Two such shared loci, IL18RAP and PTPN2, have already been identified independently in these two diseases. The aim of our study was to explicitly identify shared risk loci for these diseases by combining results from genome-wide association study (GWAS) datasets of CD and CelD. Specifically, GWAS results from CelD (768 cases, 1,422 controls) and CD (3,230 cases, 4,829 controls) were combined in a meta-analysis. Nine independent regions had nominal association p-value
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.1001283