Noncanonical inflammasomes: caspase-11 activation and effector mechanisms

[...]the observation that LPS alone is sufficient to induce caspase-11-dependent septic shock in vivo [1] would argue against a role for bacterial RNA. [...]experiments will be required to identify the bacterial signals that trigger the noncanonical inflammasome pathways and to understand the roles...

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Bibliographic Details
Published in:PLoS pathogens 2013-02, Vol.9 (2), p.e1003144-e1003144
Main Authors: Broz, Petr, Monack, Denise M
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Bacteria
Bacterial infections
Biology
Carrier Proteins - metabolism
Caspases - metabolism
Caspases, Initiator
Cytokines
E coli
Enzyme Activation
Gram-negative bacteria
Gram-Negative Bacteria - immunology
Gram-Negative Bacteria - metabolism
Gram-positive bacteria
Host-parasite relationships
Infections
Inflammasomes - metabolism
Inflammation
Macrophages - enzymology
Mice
Mice, Knockout
Microbiology
NLR Family, Pyrin Domain-Containing 3 Protein
Pearls
Phagosomes - enzymology
Physiological aspects
Proteins
Salmonella
Signal Transduction - physiology
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Summary:[...]the observation that LPS alone is sufficient to induce caspase-11-dependent septic shock in vivo [1] would argue against a role for bacterial RNA. [...]experiments will be required to identify the bacterial signals that trigger the noncanonical inflammasome pathways and to understand the roles of LPS and bacterial RNA in this process. [...]during L. pneumophila infections, caspase-11 controls phagosome-lysosome fusion through the phosphorylation state of cofilin. [...]the authors showed that caspase-11 might promote the fusion of the L. pneumophila vacuole with lysosomes by modulating actin polymerization through cofilin (Figure 1A).
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1003144