Quantitative genomics of aggressive behavior in Drosophila melanogaster

Aggressive behavior is important for animal survival and reproduction, and excessive aggression is an enormous social and economic burden for human society. Although the role of biogenic amines in modulating aggressive behavior is well characterized, other genetic mechanisms affecting this complex b...

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Bibliographic Details
Published in:PLoS genetics 2006-09, Vol.2 (9), p.e154
Main Authors: Edwards, Alexis C, Rollmann, Stephanie M, Morgan, Theodore J, Mackay, Trudy F C
Format: Article
Language:English
Subjects:
Aggression
Aggressiveness
Animals
Behavior
Behavior, Animal
Cell adhesion & migration
DNA Transposable Elements - genetics
Dopamine
Drosophila
Drosophila melanogaster
Drosophila melanogaster - genetics
Drosophila melanogaster - physiology
Eukaryotes
Gene mutations
Genes, Insect
Genetic aspects
Genetic research
Genetics
Genetics/Complex Traits
Genetics/Functional Genomics
Genetics/Gene Expression
Genomes
Genomics
Genomics - methods
Insects
Mutagenesis, Insertional
Nitric oxide
Phenotype
Selection, Genetic
Society
Transcription, Genetic
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Summary:Aggressive behavior is important for animal survival and reproduction, and excessive aggression is an enormous social and economic burden for human society. Although the role of biogenic amines in modulating aggressive behavior is well characterized, other genetic mechanisms affecting this complex behavior remain elusive. Here, we developed an assay to rapidly quantify aggressive behavior in Drosophila melanogaster, and generated replicate selection lines with divergent levels of aggression. The realized heritability of aggressive behavior was approximately 0.10, and the phenotypic response to selection specifically affected aggression. We used whole-genome expression analysis to identify 1,539 probe sets with different expression levels between the selection lines when pooled across replicates, at a false discovery rate of 0.001. We quantified the aggressive behavior of 19 mutations in candidate genes that were generated in a common co-isogenic background, and identified 15 novel genes affecting aggressive behavior. Expression profiling of genetically divergent lines is an effective strategy for identifying genes affecting complex traits.
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.0020154