Virulent synergistic effect between Enterococcus faecalis and Escherichia coli assayed by using the Caenorhabditis elegans model

The role of enterococci in the pathogenesis of polymicrobial infections is still debated. The purpose of this study was to evaluate the effect of virulent enterococci in the presence or absence of Escherichia coli strains in the in vivo Caenorhabditis elegans model. This study demonstrated that ther...

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Bibliographic Details
Published in:PloS one 2008-10, Vol.3 (10), p.e3370-e3370
Main Authors: Lavigne, Jean-Philippe, Nicolas-Chanoine, Marie-Hélène, Bourg, Gisèle, Moreau, Jérôme, Sotto, Albert
Format: Article
Language:English
Subjects:
Analysis
Animals
Anti-Bacterial Agents
Anti-Bacterial Agents - therapeutic use
Antibiotics
Bacteria
Bacterial Infections
Bacterial Infections - drug therapy
Bacterial Infections - physiopathology
Bacterial proteins
Caenorhabditis elegans
Caenorhabditis elegans - microbiology
Caenorhabditis elegans - physiology
Disease Models, Animal
Drug resistance
E coli
Ecology, environment
Endocarditis
Enterococcus faecalis
Enterococcus faecalis - pathogenicity
Enterococcus faecium
Escherichia coli
Escherichia coli - pathogenicity
Fatalities
Gastroenterology and Hepatology/Gastrointestinal Infections
Genotype
Health aspects
Immunology
In vivo methods and tests
Infections
Infectious Diseases/Bacterial Infections
Infectious Diseases/Gastrointestinal Infections
Life Sciences
Medical research
Microbiology/Cellular Microbiology and Pathogenesis
Microbiology/Immunity to Infections
Microbiology/Medical Microbiology
Microorganisms
Nematodes
Pathogenesis
Pathogens
Regression Analysis
Roundworms
Strains (organisms)
Streptococcus infections
Streptococcus mitis
Streptococcus pneumoniae
Symbiosis
Synergistic effect
Virulence
Virulence (Microbiology)
Virulence Factors
Virulence Factors - genetics
Virulence Factors - metabolism
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Summary:The role of enterococci in the pathogenesis of polymicrobial infections is still debated. The purpose of this study was to evaluate the effect of virulent enterococci in the presence or absence of Escherichia coli strains in the in vivo Caenorhabditis elegans model. This study demonstrated that there was a synergistic effect on virulence when an association of enterococci and E. coli (LT50 = 1.6 days+/-0.1 according to the tested strains and death of nematodes in 4 days+/-0.5) was tested in comparison with enterococci alone (LT50 = 4.6 days+/-0.1 and death in 10.4 days+/-0.6) or E. coli alone (LT50 = 2.1+/-0.9 and deaths 6.6+/-0.6) (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0003370