TCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention program

TCF7L2 variants have been associated with type 2 diabetes, body mass index (BMI), and deficits in proinsulin processing and insulin secretion. Here we sought to test whether these effects were apparent in high-risk individuals and modify treatment responses. We examined the potential role of the TCF...

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Bibliographic Details
Published in:PloS one 2011-07, Vol.6 (7), p.e21518-e21518
Main Authors: McCaffery, Jeanne M, Jablonski, Kathleen A, Franks, Paul W, Dagogo-Jack, Sam, Wing, Rena R, Knowler, William C, Delahanty, Linda, Dabelea, Dana, Hamman, Richard, Shuldiner, Alan R, Florez, Jose C
Format: Article
Language:English
Subjects:
Adults
Body fat
Body mass
Body Mass Index
Body size
Body weight loss
Clinical Medicine
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - genetics
Diabetes Mellitus, Type 2 - prevention & control
Diabetes therapy
Diet
Disease control
Endocrinology
Endocrinology and Diabetes
Endokrinologi och diabetes
Epidemiology
Fasting
Female
Follow-Up Studies
Gene polymorphism
Genetic aspects
Genotype
Genotypes
Glucose Tolerance Test
Haplotypes
Health risks
Hospitals
Humans
Insulin
Insulin - genetics
Insulin - metabolism
Insulin Resistance
Insulin secretion
Intervention
Klinisk medicin
Lifestyles
Male
Mass spectrometry
Medical and Health Sciences
Medicin och hälsovetenskap
Medicine
Middle Aged
Nutrition research
Polymorphism
Polymorphism, Genetic - genetics
Population
Prevention
Prevention programs
Proinsulin - genetics
Proinsulin - metabolism
Review boards
Risk
Scientific imaging
Secretion
Transcription Factor 7-Like 2 Protein - genetics
Transcription factors
Type 2 diabetes
Weight control
Weight loss
Weight Loss - genetics
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Summary:TCF7L2 variants have been associated with type 2 diabetes, body mass index (BMI), and deficits in proinsulin processing and insulin secretion. Here we sought to test whether these effects were apparent in high-risk individuals and modify treatment responses. We examined the potential role of the TCF7L2 rs7903146 variant in predicting resistance to weight loss or a lack of improvement of proinsulin processing during 2.5-years of follow-up participants (N = 2,994) from the Diabetes Prevention Program (DPP), a randomized controlled trial designed to prevent or delay diabetes in high-risk adults. We observed no difference in the degree of weight loss by rs7903146 genotypes. However, the T allele (conferring higher risk of diabetes) at rs7903146 was associated with higher fasting proinsulin at baseline (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0021518