Intraepithelial γδ T cells remain increased in the duodenum of AIDS patients despite antiretroviral treatment

Intraepithelial lymphocytes (IELs) bearing the γδ T-cell receptor are a unique intestinal subset whose function remains elusive. Here, we examine how they behave in AIDS and during various regimens of antiretroviral treatment in order to obtain mechanistic insight into their adaptive or innate funct...

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Bibliographic Details
Published in:PloS one 2012, Vol.7 (1), p.e29066
Main Authors: Nilssen, Dag E, Brandtzaeg, Per
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Acquired Immunodeficiency Syndrome - drug therapy
Acquired Immunodeficiency Syndrome - immunology
Acquired Immunodeficiency Syndrome - metabolism
Acquired Immunodeficiency Syndrome - pathology
Adaptive immunity
Adolescent
Adult
Aged
AIDS
Animal research
Anti-Retroviral Agents - pharmacology
Anti-Retroviral Agents - therapeutic use
Antiretroviral agents
Antiretroviral drugs
Biology
Case-Control Studies
CD3 antigen
CD8 antigen
Child
Child, Preschool
Coding
Cytomegalovirus
Duodenum
Duodenum - drug effects
Duodenum - immunology
Duodenum - metabolism
Epitopes
Female
Highly active antiretroviral therapy
HIV
Human immunodeficiency virus
Humans
Immune status
Immunofluorescence
Immunoglobulins
Intestinal Mucosa - drug effects
Intestinal Mucosa - immunology
Intestinal Mucosa - metabolism
Intestine
Lymphocyte Count
Lymphocytes
Lymphocytes T
Male
Medicine
Microorganisms
Middle Aged
Mucosa
Nucleoside analogs
Patients
Peripheral blood
Receptors, Antigen, T-Cell, gamma-delta - metabolism
T cell receptors
T-cell receptor
T-Lymphocytes - metabolism
T-Lymphocytes - pathology
Therapy
Up-Regulation - drug effects
Up-Regulation - physiology
Young Adult
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Summary:Intraepithelial lymphocytes (IELs) bearing the γδ T-cell receptor are a unique intestinal subset whose function remains elusive. Here, we examine how they behave in AIDS and during various regimens of antiretroviral treatment in order to obtain mechanistic insight into their adaptive or innate functional in vivo properties. IELs were studied by multimarker two-colour immunofluorescence in situ staining. Consecutive duodenal biopsies were obtained from advanced infection-prone HIV(+) patients (n = 30). The systemic adaptive immune status was monitored by determining T-cell subsets and immunoglobulins in peripheral blood. The γδ IEL ratio (median 14.5%, range 1.5-56.3%) was significantly increased (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0029066