Matrix metalloproteinase-1 and -9 in human placenta during spontaneous vaginal delivery and caesarean sectioning in preterm pregnancy

Preterm birth is a major public health problem in terms of loss of life, long-term and short term disabilities worldwide. The process of parturition (both term and preterm) involves intensive remodelling of the extracellular matrix (ECM) in the placenta and fetal membranes by matrix metalloproteinas...

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Bibliographic Details
Published in:PloS one 2012-01, Vol.7 (1), p.e29855-e29855
Main Authors: Sundrani, Deepali P, Chavan-Gautam, Preeti M, Pisal, Hemlata R, Mehendale, Savita S, Joshi, Sadhana R
Format: Article
Language:English
Subjects:
Biology
Carbon
Cesarean Section
Childbirth & labor
Delivery (Childbirth)
Diabetes
Disabilities
DNA methylation
Docosahexaenoic acid
Docosahexaenoic Acids - metabolism
Enzyme-linked immunosorbent assay
Epigenesis, Genetic
Epigenetics
Extracellular matrix
Fatty acids
Female
Fetuses
Gelatinase B
Gene expression
Homocysteine
Humans
Interstitial collagenase
Matrix metalloproteinase
Matrix Metalloproteinase 1 - genetics
Matrix Metalloproteinase 1 - metabolism
Matrix Metalloproteinase 9 - genetics
Matrix Metalloproteinase 9 - metabolism
Matrix metalloproteinases
Medicine
Membranes
Metabolism
Metalloproteinase
Models, Biological
Multiple sclerosis
Obstetrics
Omega 3 fatty acids
Oxidative stress
Parturition
Placenta
Placenta - enzymology
Pregnancy
Pregnancy Outcome
Pregnant women
Premature birth
Premature Birth - enzymology
Premature infants
Proteins
Public health
Schizophrenia
Sectioning
Smooth muscle
Studies
Unsaturated fatty acids
Vagina
Vagina - physiology
Vitamin B
Womens health
Young Adult
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Summary:Preterm birth is a major public health problem in terms of loss of life, long-term and short term disabilities worldwide. The process of parturition (both term and preterm) involves intensive remodelling of the extracellular matrix (ECM) in the placenta and fetal membranes by matrix metalloproteinases (MMPs). Our previous studies show reduced docosahexaenoic acid (DHA) in women delivering preterm. Further omega 3 fatty acids are reported to regulate MMP levels. This study was undertaken to examine the placental levels of MMPs and their association with placental DHA levels in women delivering preterm. The levels of MMP-1 and MMP-9 in 74 women delivering preterm (52 by spontaneous vaginal delivery and 22 by caesarean sectioning) and 75 women delivering at term (59 by spontaneous vaginal delivery and 16 by caesarean sectioning) were determined by enzyme-linked immunosorbent assay (ELISA) and their association with placental DHA was studied. Placental MMP-1 levels were higher (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0029855