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Matrix metalloproteinase-1 and -9 in human placenta during spontaneous vaginal delivery and caesarean sectioning in preterm pregnancy
Preterm birth is a major public health problem in terms of loss of life, long-term and short term disabilities worldwide. The process of parturition (both term and preterm) involves intensive remodelling of the extracellular matrix (ECM) in the placenta and fetal membranes by matrix metalloproteinas...
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| Published in: | PloS one 2012-01, Vol.7 (1), p.e29855-e29855 |
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| creator | Sundrani, Deepali P Chavan-Gautam, Preeti M Pisal, Hemlata R Mehendale, Savita S Joshi, Sadhana R |
| description | Preterm birth is a major public health problem in terms of loss of life, long-term and short term disabilities worldwide. The process of parturition (both term and preterm) involves intensive remodelling of the extracellular matrix (ECM) in the placenta and fetal membranes by matrix metalloproteinases (MMPs). Our previous studies show reduced docosahexaenoic acid (DHA) in women delivering preterm. Further omega 3 fatty acids are reported to regulate MMP levels. This study was undertaken to examine the placental levels of MMPs and their association with placental DHA levels in women delivering preterm. The levels of MMP-1 and MMP-9 in 74 women delivering preterm (52 by spontaneous vaginal delivery and 22 by caesarean sectioning) and 75 women delivering at term (59 by spontaneous vaginal delivery and 16 by caesarean sectioning) were determined by enzyme-linked immunosorbent assay (ELISA) and their association with placental DHA was studied. Placental MMP-1 levels were higher (p |
| doi_str_mv | 10.1371/journal.pone.0029855 |
| format | article |
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The process of parturition (both term and preterm) involves intensive remodelling of the extracellular matrix (ECM) in the placenta and fetal membranes by matrix metalloproteinases (MMPs). Our previous studies show reduced docosahexaenoic acid (DHA) in women delivering preterm. Further omega 3 fatty acids are reported to regulate MMP levels. This study was undertaken to examine the placental levels of MMPs and their association with placental DHA levels in women delivering preterm. The levels of MMP-1 and MMP-9 in 74 women delivering preterm (52 by spontaneous vaginal delivery and 22 by caesarean sectioning) and 75 women delivering at term (59 by spontaneous vaginal delivery and 16 by caesarean sectioning) were determined by enzyme-linked immunosorbent assay (ELISA) and their association with placental DHA was studied. Placental MMP-1 levels were higher (p<0.05) in women delivering preterm (both by spontaneous vaginal delivery and caesarean sectioning) as compared to those delivering at term. In contrast, placental MMP-9 levels in preterm pregnancies was higher (p<0.05) in women with spontaneous vaginal delivery while lower (p<0.05) in women delivering by caesarean sectioning. Low placental DHA was associated with higher placental MMP-9 levels. Our study suggests a differential effect of mode of delivery on the levels of MMPs from placenta. Further this study suggests a negative association of DHA and the levels of MMP-9 in human placenta although the mechanisms need further study.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0029855</identifier><identifier>PMID: 22253805</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biology ; Carbon ; Cesarean Section ; Childbirth & labor ; Delivery (Childbirth) ; Diabetes ; Disabilities ; DNA methylation ; Docosahexaenoic acid ; Docosahexaenoic Acids - metabolism ; Enzyme-linked immunosorbent assay ; Epigenesis, Genetic ; Epigenetics ; Extracellular matrix ; Fatty acids ; Female ; Fetuses ; Gelatinase B ; Gene expression ; Homocysteine ; Humans ; Interstitial collagenase ; Matrix metalloproteinase ; Matrix Metalloproteinase 1 - genetics ; Matrix Metalloproteinase 1 - metabolism ; Matrix Metalloproteinase 9 - genetics ; Matrix Metalloproteinase 9 - metabolism ; Matrix metalloproteinases ; Medicine ; Membranes ; Metabolism ; Metalloproteinase ; Models, Biological ; Multiple sclerosis ; Obstetrics ; Omega 3 fatty acids ; Oxidative stress ; Parturition ; Placenta ; Placenta - enzymology ; Pregnancy ; Pregnancy Outcome ; Pregnant women ; Premature birth ; Premature Birth - enzymology ; Premature infants ; Proteins ; Public health ; Schizophrenia ; Sectioning ; Smooth muscle ; Studies ; Unsaturated fatty acids ; Vagina ; Vagina - physiology ; Vitamin B ; Womens health ; Young Adult</subject><ispartof>PloS one, 2012-01, Vol.7 (1), p.e29855-e29855</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Sundrani et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Sundrani et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c691t-88e67906485885192036d4e55eb2da5ec54c735ffd2e037faae4bc596df719103</citedby><cites>FETCH-LOGICAL-c691t-88e67906485885192036d4e55eb2da5ec54c735ffd2e037faae4bc596df719103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1323071088/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1323071088?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792,74897</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22253805$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Schunck, Wolf-Hagen</contributor><creatorcontrib>Sundrani, Deepali P</creatorcontrib><creatorcontrib>Chavan-Gautam, Preeti M</creatorcontrib><creatorcontrib>Pisal, Hemlata R</creatorcontrib><creatorcontrib>Mehendale, Savita S</creatorcontrib><creatorcontrib>Joshi, Sadhana R</creatorcontrib><title>Matrix metalloproteinase-1 and -9 in human placenta during spontaneous vaginal delivery and caesarean sectioning in preterm pregnancy</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Preterm birth is a major public health problem in terms of loss of life, long-term and short term disabilities worldwide. The process of parturition (both term and preterm) involves intensive remodelling of the extracellular matrix (ECM) in the placenta and fetal membranes by matrix metalloproteinases (MMPs). Our previous studies show reduced docosahexaenoic acid (DHA) in women delivering preterm. Further omega 3 fatty acids are reported to regulate MMP levels. This study was undertaken to examine the placental levels of MMPs and their association with placental DHA levels in women delivering preterm. The levels of MMP-1 and MMP-9 in 74 women delivering preterm (52 by spontaneous vaginal delivery and 22 by caesarean sectioning) and 75 women delivering at term (59 by spontaneous vaginal delivery and 16 by caesarean sectioning) were determined by enzyme-linked immunosorbent assay (ELISA) and their association with placental DHA was studied. Placental MMP-1 levels were higher (p<0.05) in women delivering preterm (both by spontaneous vaginal delivery and caesarean sectioning) as compared to those delivering at term. In contrast, placental MMP-9 levels in preterm pregnancies was higher (p<0.05) in women with spontaneous vaginal delivery while lower (p<0.05) in women delivering by caesarean sectioning. Low placental DHA was associated with higher placental MMP-9 levels. Our study suggests a differential effect of mode of delivery on the levels of MMPs from placenta. Further this study suggests a negative association of DHA and the levels of MMP-9 in human placenta although the mechanisms need further study.</description><subject>Biology</subject><subject>Carbon</subject><subject>Cesarean Section</subject><subject>Childbirth & labor</subject><subject>Delivery (Childbirth)</subject><subject>Diabetes</subject><subject>Disabilities</subject><subject>DNA methylation</subject><subject>Docosahexaenoic acid</subject><subject>Docosahexaenoic Acids - metabolism</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetics</subject><subject>Extracellular matrix</subject><subject>Fatty acids</subject><subject>Female</subject><subject>Fetuses</subject><subject>Gelatinase B</subject><subject>Gene expression</subject><subject>Homocysteine</subject><subject>Humans</subject><subject>Interstitial collagenase</subject><subject>Matrix metalloproteinase</subject><subject>Matrix Metalloproteinase 1 - genetics</subject><subject>Matrix Metalloproteinase 1 - 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The process of parturition (both term and preterm) involves intensive remodelling of the extracellular matrix (ECM) in the placenta and fetal membranes by matrix metalloproteinases (MMPs). Our previous studies show reduced docosahexaenoic acid (DHA) in women delivering preterm. Further omega 3 fatty acids are reported to regulate MMP levels. This study was undertaken to examine the placental levels of MMPs and their association with placental DHA levels in women delivering preterm. The levels of MMP-1 and MMP-9 in 74 women delivering preterm (52 by spontaneous vaginal delivery and 22 by caesarean sectioning) and 75 women delivering at term (59 by spontaneous vaginal delivery and 16 by caesarean sectioning) were determined by enzyme-linked immunosorbent assay (ELISA) and their association with placental DHA was studied. Placental MMP-1 levels were higher (p<0.05) in women delivering preterm (both by spontaneous vaginal delivery and caesarean sectioning) as compared to those delivering at term. In contrast, placental MMP-9 levels in preterm pregnancies was higher (p<0.05) in women with spontaneous vaginal delivery while lower (p<0.05) in women delivering by caesarean sectioning. Low placental DHA was associated with higher placental MMP-9 levels. Our study suggests a differential effect of mode of delivery on the levels of MMPs from placenta. Further this study suggests a negative association of DHA and the levels of MMP-9 in human placenta although the mechanisms need further study.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22253805</pmid><doi>10.1371/journal.pone.0029855</doi><tpages>e29855</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-01, Vol.7 (1), p.e29855-e29855 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1323071088 |
| source | Publicly Available Content (ProQuest); PubMed Central |
| subjects | Biology Carbon Cesarean Section Childbirth & labor Delivery (Childbirth) Diabetes Disabilities DNA methylation Docosahexaenoic acid Docosahexaenoic Acids - metabolism Enzyme-linked immunosorbent assay Epigenesis, Genetic Epigenetics Extracellular matrix Fatty acids Female Fetuses Gelatinase B Gene expression Homocysteine Humans Interstitial collagenase Matrix metalloproteinase Matrix Metalloproteinase 1 - genetics Matrix Metalloproteinase 1 - metabolism Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Matrix metalloproteinases Medicine Membranes Metabolism Metalloproteinase Models, Biological Multiple sclerosis Obstetrics Omega 3 fatty acids Oxidative stress Parturition Placenta Placenta - enzymology Pregnancy Pregnancy Outcome Pregnant women Premature birth Premature Birth - enzymology Premature infants Proteins Public health Schizophrenia Sectioning Smooth muscle Studies Unsaturated fatty acids Vagina Vagina - physiology Vitamin B Womens health Young Adult |
| title | Matrix metalloproteinase-1 and -9 in human placenta during spontaneous vaginal delivery and caesarean sectioning in preterm pregnancy |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T02%3A07%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Matrix%20metalloproteinase-1%20and%20-9%20in%20human%20placenta%20during%20spontaneous%20vaginal%20delivery%20and%20caesarean%20sectioning%20in%20preterm%20pregnancy&rft.jtitle=PloS%20one&rft.au=Sundrani,%20Deepali%20P&rft.date=2012-01-12&rft.volume=7&rft.issue=1&rft.spage=e29855&rft.epage=e29855&rft.pages=e29855-e29855&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0029855&rft_dat=%3Cgale_plos_%3EA477167399%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c691t-88e67906485885192036d4e55eb2da5ec54c735ffd2e037faae4bc596df719103%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1323071088&rft_id=info:pmid/22253805&rft_galeid=A477167399&rfr_iscdi=true |