Granulocyte-colony stimulating factor (G-CSF) improves motor recovery in the rat impactor model for spinal cord injury

Granulocyte-colony stimulating factor (G-CSF) improves outcome after experimental SCI by counteracting apoptosis, and enhancing connectivity in the injured spinal cord. Previously we have employed the mouse hemisection SCI model and studied motor function after subcutaneous or transgenic delivery of...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2012-01, Vol.7 (1), p.e29880-e29880
Main Authors: Dittgen, Tanjew, Pitzer, Claudia, Plaas, Christian, Kirsch, Friederike, Vogt, Gerhard, Laage, Rico, Schneider, Armin
Format: Article
Language:English
Subjects:
Amino acids
Animals
Apoptosis
B cells
Biology
Colonies
Colony-stimulating factor
Disease Models, Animal
Female
Genetic engineering
Granulocyte colony-stimulating factor
Granulocyte Colony-Stimulating Factor - pharmacology
Granulocyte Colony-Stimulating Factor - therapeutic use
Granulocytes
Ischemia
Kinases
Leukocytes (granulocytic)
Ligands
Medicine
Mice
Motor Activity - drug effects
Neurosciences
Proteins
Rats
Rats, Wistar
Recovery (Medical)
Recovery of Function - drug effects
Regression analysis
Rodents
Spinal cord injuries
Spinal Cord Injuries - drug therapy
Spinal Cord Injuries - physiopathology
Stem cells
Stroke
Surgery
Trauma
Treatment Outcome
Trends
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Granulocyte-colony stimulating factor (G-CSF) improves outcome after experimental SCI by counteracting apoptosis, and enhancing connectivity in the injured spinal cord. Previously we have employed the mouse hemisection SCI model and studied motor function after subcutaneous or transgenic delivery of the protein. To further broaden confidence in animal efficacy data we sought to determine efficacy in a different model and a different species. Here we investigated the effects of G-CSF in Wistar rats using the New York University Impactor. In this model, corroborating our previous data, rats treated subcutaneously with G-CSF over 2 weeks show significant improvement of motor function.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0029880