Maternal and fetal placental growth hormone and IGF axis in type 1 diabetic pregnancy

Placental growth hormone (PGH) is a major growth hormone in pregnancy and acts with Insulin Like Growth Factor I (IGF-I) and Insulin Like Growth Hormone Binding Protein 3 (IGFBP3). The aim of this study was to investigate PGH, IGF-I and IGFBP3 in non-diabetic (ND) compared to Type 1 Diabetic (T1DM)...

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Bibliographic Details
Published in:PloS one 2012-02, Vol.7 (2), p.e29164-e29164
Main Authors: Higgins, Mary F, Russell, Noirin E, Crossey, Paul A, Nyhan, Kristine C, Brazil, Derek P, McAuliffe, Fionnuala M
Format: Article
Language:English
Subjects:
Adult
Age
Biomedical research
Birth Weight
Blotting, Western
Body mass index
Childbirth & labor
Cord blood
Correlation
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 1 - blood
Enzyme-linked immunosorbent assay
Female
Fetus - metabolism
Gestation
Gestational diabetes
Glucose
Glycerol
Glycosylated hemoglobin
Growth factors
Growth hormone
Growth Hormone - blood
Growth hormones
Gynecology
Hemoglobin
Humans
Hypoglycemia
Immunoblotting
Infants
Insulin
Insulin resistance
Insulin-Like Growth Factor Binding Protein 3 - blood
Insulin-like growth factor I
Insulin-Like Growth Factor I - metabolism
Insulin-like growth factor-binding protein 3
Medicine
Metabolism
Musculoskeletal system
Obstetrics
Physical growth
Placenta
Placenta - metabolism
Placental Hormones - blood
Pregnancy
Pregnancy in Diabetics - blood
Protein binding
Proteins
Proteolysis
Regulation
Somatotropin
Type 1 diabetes
Ultrasonography, Prenatal
Ultrasound
Young Adult
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Summary:Placental growth hormone (PGH) is a major growth hormone in pregnancy and acts with Insulin Like Growth Factor I (IGF-I) and Insulin Like Growth Hormone Binding Protein 3 (IGFBP3). The aim of this study was to investigate PGH, IGF-I and IGFBP3 in non-diabetic (ND) compared to Type 1 Diabetic (T1DM) pregnancies. This is a prospective study. Maternal samples were obtained from 25 ND and 25 T1DM mothers at 36 weeks gestation. Cord blood was obtained after delivery. PGH, IGF-I and IGFBP3 were measured using ELISA. There was no difference in delivery type, gender of infants or birth weight between groups. In T1DM, maternal PGH significantly correlated with ultrasound estimated fetal weight (r = 0.4, p = 0.02), birth weight (r = 0.51, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0029164