Maternal and fetal placental growth hormone and IGF axis in type 1 diabetic pregnancy

Placental growth hormone (PGH) is a major growth hormone in pregnancy and acts with Insulin Like Growth Factor I (IGF-I) and Insulin Like Growth Hormone Binding Protein 3 (IGFBP3). The aim of this study was to investigate PGH, IGF-I and IGFBP3 in non-diabetic (ND) compared to Type 1 Diabetic (T1DM)...

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Published in:PloS one 2012-02, Vol.7 (2), p.e29164-e29164
Main Authors: Higgins, Mary F, Russell, Noirin E, Crossey, Paul A, Nyhan, Kristine C, Brazil, Derek P, McAuliffe, Fionnuala M
Format: Article
Language:English
Subjects:
Adult
Age
Biomedical research
Birth Weight
Blotting, Western
Body mass index
Childbirth & labor
Cord blood
Correlation
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 1 - blood
Enzyme-linked immunosorbent assay
Female
Fetus - metabolism
Gestation
Gestational diabetes
Glucose
Glycerol
Glycosylated hemoglobin
Growth factors
Growth hormone
Growth Hormone - blood
Growth hormones
Gynecology
Hemoglobin
Humans
Hypoglycemia
Immunoblotting
Infants
Insulin
Insulin resistance
Insulin-Like Growth Factor Binding Protein 3 - blood
Insulin-like growth factor I
Insulin-Like Growth Factor I - metabolism
Insulin-like growth factor-binding protein 3
Medicine
Metabolism
Musculoskeletal system
Obstetrics
Physical growth
Placenta
Placenta - metabolism
Placental Hormones - blood
Pregnancy
Pregnancy in Diabetics - blood
Protein binding
Proteins
Proteolysis
Regulation
Somatotropin
Type 1 diabetes
Ultrasonography, Prenatal
Ultrasound
Young Adult
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cited_by cdi_FETCH-LOGICAL-c757t-9e053eee2f961f91d1544b893c213c1ff16d11a412f326663a991aba1180cc663
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creator Higgins, Mary F
Russell, Noirin E
Crossey, Paul A
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Brazil, Derek P
McAuliffe, Fionnuala M
description Placental growth hormone (PGH) is a major growth hormone in pregnancy and acts with Insulin Like Growth Factor I (IGF-I) and Insulin Like Growth Hormone Binding Protein 3 (IGFBP3). The aim of this study was to investigate PGH, IGF-I and IGFBP3 in non-diabetic (ND) compared to Type 1 Diabetic (T1DM) pregnancies. This is a prospective study. Maternal samples were obtained from 25 ND and 25 T1DM mothers at 36 weeks gestation. Cord blood was obtained after delivery. PGH, IGF-I and IGFBP3 were measured using ELISA. There was no difference in delivery type, gender of infants or birth weight between groups. In T1DM, maternal PGH significantly correlated with ultrasound estimated fetal weight (r = 0.4, p = 0.02), birth weight (r = 0.51, p
doi_str_mv 10.1371/journal.pone.0029164
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The aim of this study was to investigate PGH, IGF-I and IGFBP3 in non-diabetic (ND) compared to Type 1 Diabetic (T1DM) pregnancies. This is a prospective study. Maternal samples were obtained from 25 ND and 25 T1DM mothers at 36 weeks gestation. Cord blood was obtained after delivery. PGH, IGF-I and IGFBP3 were measured using ELISA. There was no difference in delivery type, gender of infants or birth weight between groups. In T1DM, maternal PGH significantly correlated with ultrasound estimated fetal weight (r = 0.4, p = 0.02), birth weight (r = 0.51, p&lt;0.05) and birth weight centile (r = 0.41, p = 0.03) PGH did not correlate with HbA1c. Maternal IGF-I was lower in T1DM (p = 0.03). Maternal and fetal serum IGFBP3 was higher in T1DM. Maternal third trimester T1DM serum had a significant band at 16 kD on western blot, which was not present in ND. Maternal T1DM PGH correlated with both antenatal fetal weight and birth weight, suggesting a significant role for PGH in growth in diabetic pregnancy. IGFBP3 is significantly increased in maternal and fetal serum in T1DM pregnancies compared to ND controls, which was explained by increased proteolysis in maternal but not fetal serum. 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blood</subject><subject>Insulin-like growth factor I</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Insulin-like growth factor-binding protein 3</subject><subject>Medicine</subject><subject>Metabolism</subject><subject>Musculoskeletal system</subject><subject>Obstetrics</subject><subject>Physical growth</subject><subject>Placenta</subject><subject>Placenta - metabolism</subject><subject>Placental Hormones - blood</subject><subject>Pregnancy</subject><subject>Pregnancy in Diabetics - blood</subject><subject>Protein binding</subject><subject>Proteins</subject><subject>Proteolysis</subject><subject>Regulation</subject><subject>Somatotropin</subject><subject>Type 1 diabetes</subject><subject>Ultrasonography, Prenatal</subject><subject>Ultrasound</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNksFu1DAQhiMEoqXwBggiIYE47OKxEye-IFUVLSsVVQLK1Zo4TtarbJzaCXTfHqebVhvUA_LB4_E3_4zHE0WvgSyBZfBpYwfXYrPsbKuXhFABPHkSHYNgdMEpYU8P7KPohfcbQlKWc_48OqKUcZYQchxdf8NejzoxtmVc6T5YXYNKt6NVO_unX8dr67Yhyx2yujiP8db42LRxv-t0DHFpsNC9UXHndN1iq3Yvo2cVNl6_mvaT6Pr8y8-zr4vLq4vV2enlQmVp1i-EDhVprWklOFQCSkiTpMgFUxSYgqoCXgJgArRilHPOUAjAAgFyolQ4n0Rv97pdY72cOuIlMMrSNE8BArHaE6XFjeyc2aLbSYtG3jmsqyW6UHujJUeR5VrkFcMkKYskp1yUWFDGCgKKkaD1eco2FFtdjj1y2MxE5zetWcva_paM5pADDQIfJgFnbwbte7k1XummwVbbwUsRys6Y4GOqd_-Qjz9uomoM9Zu2siGtGjXlaZJlJEt5mgdq-QgVVqm3RoV_rUzwzwI-zgIC0-vbvsbBe7n68f3_2atfc_b9AbvW2PRrb5uhN7b1czDZg8pZ752uHnoMRI7Df98NOQ6_nIY_hL05_J-HoPtpZ38Bx5H80w</recordid><startdate>20120217</startdate><enddate>20120217</enddate><creator>Higgins, Mary F</creator><creator>Russell, Noirin E</creator><creator>Crossey, Paul A</creator><creator>Nyhan, Kristine C</creator><creator>Brazil, Derek P</creator><creator>McAuliffe, Fionnuala M</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120217</creationdate><title>Maternal and fetal placental growth hormone and IGF axis in type 1 diabetic pregnancy</title><author>Higgins, Mary F ; Russell, Noirin E ; Crossey, Paul A ; Nyhan, Kristine C ; Brazil, Derek P ; McAuliffe, Fionnuala M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c757t-9e053eee2f961f91d1544b893c213c1ff16d11a412f326663a991aba1180cc663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Age</topic><topic>Biomedical research</topic><topic>Birth Weight</topic><topic>Blotting, Western</topic><topic>Body mass index</topic><topic>Childbirth &amp; labor</topic><topic>Cord blood</topic><topic>Correlation</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Female</topic><topic>Fetus - metabolism</topic><topic>Gestation</topic><topic>Gestational diabetes</topic><topic>Glucose</topic><topic>Glycerol</topic><topic>Glycosylated hemoglobin</topic><topic>Growth factors</topic><topic>Growth hormone</topic><topic>Growth Hormone - blood</topic><topic>Growth hormones</topic><topic>Gynecology</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Hypoglycemia</topic><topic>Immunoblotting</topic><topic>Infants</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Insulin-Like Growth Factor Binding Protein 3 - blood</topic><topic>Insulin-like growth factor I</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Insulin-like growth factor-binding protein 3</topic><topic>Medicine</topic><topic>Metabolism</topic><topic>Musculoskeletal system</topic><topic>Obstetrics</topic><topic>Physical growth</topic><topic>Placenta</topic><topic>Placenta - metabolism</topic><topic>Placental Hormones - 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The aim of this study was to investigate PGH, IGF-I and IGFBP3 in non-diabetic (ND) compared to Type 1 Diabetic (T1DM) pregnancies. This is a prospective study. Maternal samples were obtained from 25 ND and 25 T1DM mothers at 36 weeks gestation. Cord blood was obtained after delivery. PGH, IGF-I and IGFBP3 were measured using ELISA. There was no difference in delivery type, gender of infants or birth weight between groups. In T1DM, maternal PGH significantly correlated with ultrasound estimated fetal weight (r = 0.4, p = 0.02), birth weight (r = 0.51, p&lt;0.05) and birth weight centile (r = 0.41, p = 0.03) PGH did not correlate with HbA1c. Maternal IGF-I was lower in T1DM (p = 0.03). Maternal and fetal serum IGFBP3 was higher in T1DM. Maternal third trimester T1DM serum had a significant band at 16 kD on western blot, which was not present in ND. Maternal T1DM PGH correlated with both antenatal fetal weight and birth weight, suggesting a significant role for PGH in growth in diabetic pregnancy. IGFBP3 is significantly increased in maternal and fetal serum in T1DM pregnancies compared to ND controls, which was explained by increased proteolysis in maternal but not fetal serum. These results suggest that the normal PGH-IGF-I-IGFBP3 axis in pregnancy is abnormal in T1DM pregnancies, which are at higher risk of macrosomia.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22363400</pmid><doi>10.1371/journal.pone.0029164</doi><tpages>e29164</tpages><oa>free_for_read</oa></addata></record>
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source Open Access: PubMed Central; Access via ProQuest (Open Access)
subjects Adult
Age
Biomedical research
Birth Weight
Blotting, Western
Body mass index
Childbirth & labor
Cord blood
Correlation
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 1 - blood
Enzyme-linked immunosorbent assay
Female
Fetus - metabolism
Gestation
Gestational diabetes
Glucose
Glycerol
Glycosylated hemoglobin
Growth factors
Growth hormone
Growth Hormone - blood
Growth hormones
Gynecology
Hemoglobin
Humans
Hypoglycemia
Immunoblotting
Infants
Insulin
Insulin resistance
Insulin-Like Growth Factor Binding Protein 3 - blood
Insulin-like growth factor I
Insulin-Like Growth Factor I - metabolism
Insulin-like growth factor-binding protein 3
Medicine
Metabolism
Musculoskeletal system
Obstetrics
Physical growth
Placenta
Placenta - metabolism
Placental Hormones - blood
Pregnancy
Pregnancy in Diabetics - blood
Protein binding
Proteins
Proteolysis
Regulation
Somatotropin
Type 1 diabetes
Ultrasonography, Prenatal
Ultrasound
Young Adult
title Maternal and fetal placental growth hormone and IGF axis in type 1 diabetic pregnancy
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