Are long-term non-progressors very slow progressors? Insights from the Chelsea and Westminster HIV cohort, 1988-2010

Define and identify long-term non-progressors (LTNP) and HIV controllers (HIC), and estimate time until disease progression. LTNP are HIV-1(+) patients who maintain stable CD4(+) T-cell counts, with no history of opportunistic infection or antiretroviral therapy (ART). HIC are a subset of LTNP who a...

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Bibliographic Details
Published in:PloS one 2012-02, Vol.7 (2), p.e29844-e29844
Main Authors: Mandalia, Sundhiya, Westrop, Samantha J, Beck, Eduard J, Nelson, Mark, Gazzard, Brian G, Imami, Nesrina
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
AIDS
Analysis
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Biology
CD4 antigen
CD4 Lymphocyte Count
Cell survival
Cohort Studies
Demography
Development and progression
Disease control
Disease Progression
Ethics
Female
Health aspects
Highly active antiretroviral therapy
HIV
HIV Infections - immunology
HIV Infections - pathology
HIV Infections - virology
HIV Long-Term Survivors
HIV-1 - physiology
Hospitals
Human immunodeficiency virus
Humans
Infection
Infections
Laboratories
London
Lymphocytes T
Male
Medical diagnosis
Medical research
Medicine
Opportunist infection
Patients
Plasma
Ribonucleic acid
RNA
Studies
T cells
Time Factors
Trends
Viremia
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Summary:Define and identify long-term non-progressors (LTNP) and HIV controllers (HIC), and estimate time until disease progression. LTNP are HIV-1(+) patients who maintain stable CD4(+) T-cell counts, with no history of opportunistic infection or antiretroviral therapy (ART). HIC are a subset of LTNP who additionally have undetectable viraemia. These individuals may provide insights for prophylactic and therapeutic development. Records of HIV-1(+) individuals attending Chelsea and Westminster Hospital (1988-2010), were analysed. LTNP were defined as: HIV-1(+) for >7 years; ART-naïve; no history of opportunistic infection and normal, stable CD4(+) T-cell counts. MIXED procedure in SAS using random intercept model identified long-term stable CD4(+) T-cell counts. Survival analysis estimated time since diagnosis until disease progression. Subjects exhibiting long-term stable CD4(+) T-cell counts with history below the normal range (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0029844