Age as a determinant for dissemination of seasonal and pandemic influenza: an open cohort study of influenza outbreaks in Östergötland County, Sweden

An understanding of the occurrence and comparative timing of influenza infections in different age groups is important for developing community response and disease control measures. This study uses data from a Scandinavian county (population 427.000) to investigate whether age was a determinant for...

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Published in:PloS one 2012, Vol.7 (2), p.e31746-e31746
Main Authors: Timpka, Toomas, Eriksson, Olle, Spreco, Armin, Gursky, Elin A, Strömgren, Magnus, Holm, Einar, Ekberg, Joakim, Dahlström, Orjan, Valter, Lars, Eriksson, Henrik
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Age groups
Aged, 80 and over
Child
Child, Preschool
Cohort analysis
Cohort Studies
Correlation analysis
Councils
Data collection
Demographics
Diagnosis
Disease control
Disease Outbreaks
Electronic medical records
Female
Health sciences
Health surveillance
Humans
Infant
Infant, Newborn
Infections
Infectious diseases
Influenza
Influenza, Human - epidemiology
Influenza, Human - physiopathology
Information science
Male
Mathematics
Medicine
Outbreaks
Pandemics
Population
Public health
Regression Analysis
School closures
Seasons
Statistical analysis
Studies
Surveillance
Sweden
Swine flu
Variance analysis
Viruses
Young adults
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creator Timpka, Toomas
Eriksson, Olle
Spreco, Armin
Gursky, Elin A
Strömgren, Magnus
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Ekberg, Joakim
Dahlström, Orjan
Valter, Lars
Eriksson, Henrik
description An understanding of the occurrence and comparative timing of influenza infections in different age groups is important for developing community response and disease control measures. This study uses data from a Scandinavian county (population 427.000) to investigate whether age was a determinant for being diagnosed with influenza 2005-2010 and to examine if age was associated with case timing during outbreaks. Aggregated demographic data were collected from Statistics Sweden, while influenza case data were collected from a county-wide electronic health record system. A logistic regression analysis was used to explore whether case risk was associated with age and outbreak. An analysis of variance was used to explore whether day for diagnosis was also associated to age and outbreak. The clinical case data were validated against case data from microbiological laboratories during one control year. The proportion of cases from the age groups 10-19 (p
doi_str_mv 10.1371/journal.pone.0031746
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An interaction between age and outbreak was observed (p<0.001) indicating a difference in age effects between circulating virus types; this interaction persisted for seasonal outbreaks only (p<0.001). The outbreaks also differed regarding when the age groups received their diagnosis (p<0.001). A post-hoc analysis showed a tendency for the young age groups, in particular the group 10-19 year olds, led outbreaks with influenza type A H1 circulating, while A H3N2 outbreaks displayed little variations in timing. The validation analysis showed a strong correlation (r = 0.625;p<0.001) between the recorded numbers of clinically and microbiologically defined influenza cases. Our findings demonstrate the complexity of age effects underlying the emergence of local influenza outbreaks. 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language eng
recordid cdi_plos_journals_1323858914
source Open Access: PubMed Central; Publicly Available Content Database (ProQuest Open Access資料庫)
subjects Adolescent
Adult
Age
Age groups
Aged, 80 and over
Child
Child, Preschool
Cohort analysis
Cohort Studies
Correlation analysis
Councils
Data collection
Demographics
Diagnosis
Disease control
Disease Outbreaks
Electronic medical records
Female
Health sciences
Health surveillance
Humans
Infant
Infant, Newborn
Infections
Infectious diseases
Influenza
Influenza, Human - epidemiology
Influenza, Human - physiopathology
Information science
Male
Mathematics
Medicine
Outbreaks
Pandemics
Population
Public health
Regression Analysis
School closures
Seasons
Statistical analysis
Studies
Surveillance
Sweden
Swine flu
Variance analysis
Viruses
Young adults
title Age as a determinant for dissemination of seasonal and pandemic influenza: an open cohort study of influenza outbreaks in Östergötland County, Sweden
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