Compositional development of Bifidobacterium and Lactobacillus microbiota is linked with crying and fussing in early infancy

Our aim was to establish whether there is an interconnection between the compositional development of the gut microbiota and the amount of fussing and crying in early infancy. Behavioral patterns of 89 infants during the 7(th) and 12(th) week of life were recorded in parental diaries. Total distress...

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Bibliographic Details
Published in:PloS one 2012-03, Vol.7 (3), p.e32495-e32495
Main Authors: Pärtty, Anna, Kalliomäki, Marko, Endo, Akihito, Salminen, Seppo, Isolauri, Erika
Format: Article
Language:English
Subjects:
Age
Allergies
Babies
Bacteria
Bifidobacterium - genetics
Bifidobacterium - isolation & purification
Bifidobacterium breve
Biochemistry
Biology
Breastfeeding & lactation
Crying
Cytokines
Dendritic cells
Deoxyribonucleic acid
Diaries
Digestive tract
DNA
Female
Functional foods & nutraceuticals
Gastrointestinal Tract - microbiology
Genetic testing
Humans
Infant
Infant Behavior
Infants
Intestinal microflora
Lactobacillus
Lactobacillus - genetics
Lactobacillus - isolation & purification
Lactobacillus rhamnosus
Male
Medicine
Metagenome
Microbiota
Microbiota (Symbiotic organisms)
Parenting
Parents & parenting
Pediatrics
Population
Time Factors
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Summary:Our aim was to establish whether there is an interconnection between the compositional development of the gut microbiota and the amount of fussing and crying in early infancy. Behavioral patterns of 89 infants during the 7(th) and 12(th) week of life were recorded in parental diaries. Total distress was defined as the sum of daily amounts of crying and fussing. Infants' gut microbiota profiles were investigated by several molecular assays during the first six months of life. The median (range) duration of total distress among the infants was 106 (0-478) minutes a day during the 7(th) and 58 (0-448) minutes a day during the 12(th) week. The proportion of Bifidobacterium counts to total bacterial counts was inversely associated with the amount of crying and fussing during the first 3 months of life (p = 0.03), although the number of Bifidobacterium breve was positively associated with total distress (p = 0.02). The frequency of Lactobacillus spp. at the age of 3 weeks was inversely associated with total infant distress during the 7(th) week of life (p = 0.02). Bifidobacterium and Lactobacillus appear to protect against crying and fussing. Identification of specific strains with optimal protective properties would benefit at-risk infants.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0032495