An analysis of 332 fatalities infected with pandemic 2009 influenza A (H1N1) in Argentina

The apparent high number of deaths in Argentina during the 2009 pandemic led to concern that the influenza A H1N1pdm disease was different there. We report the characteristics and risk factors for influenza A H1N1pdm fatalities. We identified laboratory-confirmed influenza A H1N1pdm fatalities occur...

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Published in:PloS one 2012-04, Vol.7 (4), p.e33670-e33670
Main Authors: Balanzat, Ana M, Hertlein, Christian, Apezteguia, Carlos, Bonvehi, Pablo, Cámera, Luis, Gentile, Angela, Rizzo, Oscar, Gómez-Carrillo, Manuel, Coronado, Fatima, Azziz-Baumgartner, Eduardo, Chávez, Pollyanna R, Widdowson, Marc-Alain
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adult respiratory distress syndrome
Aged
Antiviral agents
Argentina - epidemiology
Biology
Child
Child, Preschool
Children
Cross infection
Disease Outbreaks
Fatalities
Female
Humans
Identification methods
Immunization
Infant
Infant, Newborn
Influenza
Influenza A
Influenza A Virus, H1N1 Subtype
Influenza, Human - epidemiology
Influenza, Human - mortality
Influenza, Human - virology
Laboratories
Lung diseases
Male
Medical personnel
Medicine
Middle Aged
Mortality
Neonates
Pandemics
Patients
Physicians
Postpartum
Pregnancy
Pregnant women
Respiratory failure
Risk analysis
Risk Factors
Swine flu
Young Adult
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cited_by cdi_FETCH-LOGICAL-c593t-2d19d41419d0d30c336c9b96a4d11ccfd26a90a04d284652a5405287bcaf9d943
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container_title PloS one
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creator Balanzat, Ana M
Hertlein, Christian
Apezteguia, Carlos
Bonvehi, Pablo
Cámera, Luis
Gentile, Angela
Rizzo, Oscar
Gómez-Carrillo, Manuel
Coronado, Fatima
Azziz-Baumgartner, Eduardo
Chávez, Pollyanna R
Widdowson, Marc-Alain
description The apparent high number of deaths in Argentina during the 2009 pandemic led to concern that the influenza A H1N1pdm disease was different there. We report the characteristics and risk factors for influenza A H1N1pdm fatalities. We identified laboratory-confirmed influenza A H1N1pdm fatalities occurring during June-July 2009. Physicians abstracted data on age, sex, time of onset of illness, medical history, clinical presentation at admission, laboratory, treatment, and outcomes using standardize questionnaires. We explored the characteristics of fatalities according to their age and risk group. Of 332 influenza A H1N1pdm fatalities, 226 (68%) were among persons aged
doi_str_mv 10.1371/journal.pone.0033670
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We report the characteristics and risk factors for influenza A H1N1pdm fatalities. We identified laboratory-confirmed influenza A H1N1pdm fatalities occurring during June-July 2009. Physicians abstracted data on age, sex, time of onset of illness, medical history, clinical presentation at admission, laboratory, treatment, and outcomes using standardize questionnaires. We explored the characteristics of fatalities according to their age and risk group. Of 332 influenza A H1N1pdm fatalities, 226 (68%) were among persons aged &lt;50 years. Acute respiratory failure was the leading cause of death. Of all cases, 249 (75%) had at least one comorbidity as defined by Advisory Committee on Immunization Practices. Obesity was reported in 32% with data and chronic pulmonary disease in 28%. Among the 40 deaths in children aged &lt;5 years, chronic pulmonary disease (42%) and neonatal pathologies (35%) were the most common co-morbidities. Twenty (6%) fatalities were among pregnant or postpartum women of which only 47% had diagnosed co-morbidities. Only 13% of patients received antiviral treatment within 48 hours of symptom onset. None of children aged &lt;5 years or the pregnant women received antivirals within 48 h of symptom onset. As the pandemic progressed, the time from symptom-onset to medical care and to antiviral treatment decreased significantly among case-patients who subsequently died (p&lt;0.001). Persons with co-morbidities, pregnant and who received antivirals late were over-represented among influenza A H1N1pdm deaths in Argentina, though timeliness of antiviral treatment improved during the pandemic.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22506006</pmid><doi>10.1371/journal.pone.0033670</doi><oa>free_for_read</oa></addata></record>
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source Open Access: PubMed Central; Publicly Available Content Database
subjects Adolescent
Adult
Adult respiratory distress syndrome
Aged
Antiviral agents
Argentina - epidemiology
Biology
Child
Child, Preschool
Children
Cross infection
Disease Outbreaks
Fatalities
Female
Humans
Identification methods
Immunization
Infant
Infant, Newborn
Influenza
Influenza A
Influenza A Virus, H1N1 Subtype
Influenza, Human - epidemiology
Influenza, Human - mortality
Influenza, Human - virology
Laboratories
Lung diseases
Male
Medical personnel
Medicine
Middle Aged
Mortality
Neonates
Pandemics
Patients
Physicians
Postpartum
Pregnancy
Pregnant women
Respiratory failure
Risk analysis
Risk Factors
Swine flu
Young Adult
title An analysis of 332 fatalities infected with pandemic 2009 influenza A (H1N1) in Argentina
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