Structural olfactory nerve changes in patients suffering from idiopathic intracranial hypertension

Complications of idiopathic intracranial hypertension (IIH) are usually caused by elevated intracranial pressure (ICP). In a similar way as in the optic nerve, elevated ICP could also compromise the olfactory nerve system. On the other side, there is growing evidence that an extensive lymphatic netw...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2012-04, Vol.7 (4), p.e35221-e35221
Main Authors: Schmidt, Christoph, Wiener, Edzard, Hoffmann, Jan, Klingebiel, Randolf, Schmidt, Felix, Hofmann, Tobias, Harms, Lutz, Kunte, Hagen
Format: Article
Language:English
Subjects:
Adult
Biology
Case-Control Studies
Cerebrospinal fluid
Complications
Female
Humans
Hypertension
Identification
Intracranial hypertension
Intracranial Hypertension - complications
Intracranial Hypertension - pathology
Intracranial Hypertension - physiopathology
Intracranial pressure
Magnetic resonance
Magnetic Resonance Imaging
Male
Medical research
Medicine
Mental depression
Middle Aged
Nerves
Neurology
NMR
Nuclear magnetic resonance
Odors
Olfactory bulb
Olfactory Bulb - pathology
Olfactory Bulb - physiopathology
Olfactory nerve
Olfactory Nerve - pathology
Olfactory Nerve - physiopathology
Optic nerve
Parkinson's disease
Parkinsons disease
Patients
Pilot Projects
Pseudotumor Cerebri - complications
Pseudotumor Cerebri - pathology
Pseudotumor Cerebri - physiopathology
Quality of life
Rodents
Smell
Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Complications of idiopathic intracranial hypertension (IIH) are usually caused by elevated intracranial pressure (ICP). In a similar way as in the optic nerve, elevated ICP could also compromise the olfactory nerve system. On the other side, there is growing evidence that an extensive lymphatic network system around the olfactory nerves could be disturbed in cerebrospinal fluid disorders like IIH. The hypothesis that patients with IIH suffer from hyposmia has been suggested in the past. However, this has not been proven in clinical studies yet. This pilot study investigates whether structural changes of the olfactory nerve system can be detected in patients with IIH. Twenty-three patients with IIH and 23 matched controls were included. Olfactory bulb volume (OBV) and sulcus olfactorius (OS) depth were calculated by magnetic resonance techniques. While mean values of total OBV (128.7±38.4 vs. 130.0±32.6 mm(3), p=0.90) and mean OS depth (8.5±1.2 vs. 8.6±1.1 mm, p=0.91) were similar in both groups, Pearson correlation showed that patients with a shorter medical history IIH revealed a smaller OBV (r=0.53, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0035221