Evidence of differential allelic effects between adolescents and adults for plasma high-density lipoprotein

A recent meta-analysis of genome-wide association (GWA) studies identified 95 loci that influence lipid traits in the adult population and found that collectively these explained about 25-30% of heritability for each trait. Little is known about how these loci affect lipid levels in early life, but...

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Bibliographic Details
Published in:PloS one 2012-04, Vol.7 (4), p.e35605-e35605
Main Authors: Middelberg, Rita P S, Heath, Andrew C, Madden, Pamela A F, Montgomery, Grant W, Martin, Nicholas G, Whitfield, John B
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Adult
Adults
Alcoholism
Alleles
Analysis
Australians
Biology
Blood cholesterol
Child
Cholesterol
Cholesterol tests
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Epidemiology
Family studies
Female
Genetic aspects
Genetic Association Studies
Genetic diversity
Genetic effects
Genetic variance
Genomes
Genomics
Genotype
Heritability
Heterogeneity
High density lipoprotein
Humans
Hyperlipoproteinemias - blood
Hyperlipoproteinemias - genetics
Lipids
Loci
Low density lipoprotein
Low density lipoprotein receptors
Low density lipoproteins
Male
Medicine
Meta-analysis
Middle Aged
Polymorphism, Single Nucleotide
Teenagers
Triglycerides
Triglycerides - blood
Young Adult
Youth
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Summary:A recent meta-analysis of genome-wide association (GWA) studies identified 95 loci that influence lipid traits in the adult population and found that collectively these explained about 25-30% of heritability for each trait. Little is known about how these loci affect lipid levels in early life, but there is evidence that genetic effects on HDL- and LDL-cholesterol (HDL-C, LDL-C) and triglycerides vary with age. We studied Australian adults (N = 10,151) and adolescents (N = 2,363) who participated in twin and family studies and for whom we have lipid phenotypes and genotype information for 91 of the 95 genetic variants. Heterogeneity tests between effect sizes in adult and adolescent cohorts showed an excess of heterogeneity for HDL-C (p(Het)
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0035605