Betaine and secondary events in an acute coronary syndrome cohort

Betaine insufficiency is associated with unfavourable vascular risk profiles in metabolic syndrome patients. We investigated associations between betaine insufficiency and secondary events in acute coronary syndrome patients. Plasma (531) and urine (415) samples were collected four months after disc...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2012-05, Vol.7 (5), p.e37883-e37883
Main Authors: Lever, Michael, George, Peter M, Elmslie, Jane L, Atkinson, Wendy, Slow, Sandy, Molyneux, Sarah L, Troughton, Richard W, Richards, A Mark, Frampton, Christopher M, Chambers, Stephen T
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - blood
Acute Coronary Syndrome - complications
Acute Coronary Syndrome - urine
Acute coronary syndromes
Aged
Aged, 80 and over
Apolipoproteins
Betaine
Betaine - blood
Betaine - metabolism
Betaine - urine
Biochemistry
Biology
Cardiac patients
Chromatography, High Pressure Liquid
Cohort Studies
Comparative analysis
Diabetes
Diabetes mellitus
Diabetics
Dimethylglycine
Excretion
Female
Folic acid
Heart attack
Heart diseases
Heart failure
Heart Failure - blood
Heart Failure - etiology
Heart Failure - urine
Homocysteine
Homocysteine - blood
Hospital patients
Humans
Infarction
Kaplan-Meier Estimate
Laboratories
Linear Models
Lipids
Liver cancer
Male
Medical research
Medicine
Metabolic disorders
Metabolic syndrome
Metabolites
Middle Aged
Myocardial infarction
Myocardial Infarction - blood
Myocardial Infarction - etiology
Myocardial Infarction - urine
New Zealand
Pathology
Patients
Risk
Risk Factors
Rodents
Sarcosine - analogs & derivatives
Sarcosine - blood
Supplementation
Supplements
Urine
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Betaine insufficiency is associated with unfavourable vascular risk profiles in metabolic syndrome patients. We investigated associations between betaine insufficiency and secondary events in acute coronary syndrome patients. Plasma (531) and urine (415) samples were collected four months after discharge following an acute coronary event. Death (34), secondary acute myocardial infarction (MI) (70) and hospital admission for heart failure (45) events were recorded over a median follow-up of 832 days. The highest and lowest quintiles of urinary betaine excretion associated with risk of heart failure (p = 0.0046, p = 0.013 compared with middle 60%) but not with subsequent acute MI. The lowest quintile of plasma betaine was associated with subsequent acute MI (p = 0.014), and the top quintile plasma betaine with heart failure (p = 0.043), especially in patients with diabetes (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0037883