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Glycophenotypic alterations induced by Pteridium aquilinum in mice gastric mucosa: synergistic effect with Helicobacter pylori infection
The bracken fern Pteridium aquilinum is a plant known to be carcinogenic to animals. Epidemiological studies have shown an association between bracken fern exposure and gastric cancer development in humans. The biological effects of exposure to this plant within the gastric carcinogenesis process ar...
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| Published in: | PloS one 2012-06, Vol.7 (6), p.e38353 |
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| creator | Gomes, Joana Magalhães, Ana Carvalho, Ana S Hernandez, Gilberto E Papp, Suzanne L Head, Steven R Michel, Valérie David, Leonor Gärtner, Fátima Touati, Eliette Reis, Celso A |
| description | The bracken fern Pteridium aquilinum is a plant known to be carcinogenic to animals. Epidemiological studies have shown an association between bracken fern exposure and gastric cancer development in humans. The biological effects of exposure to this plant within the gastric carcinogenesis process are not fully understood. In the present work, effects in the gastric mucosa of mice treated with Pteridium aquilinum were evaluated, as well as molecular mechanisms underlying the synergistic role with Helicobacter pylori infection. Our results showed that exposure to Pteridium aquilinum induces histomorphological modifications including increased expression of acidic glycoconjugates in the gastric mucosa. The transcriptome analysis of gastric mucosa showed that upon exposure to Pteridium aquilinum several glycosyltransferase genes were differently expressed, including Galntl4, C1galt1 and St3gal2, that are mainly involved in the biosynthesis of simple mucin-type carbohydrate antigens. Concomitant treatment with Pteridium aquilinum and infection with Helicobacter pylori also resulted in differently expressed glycosyltransferase genes underlying the biosynthesis of terminal sialylated Lewis antigens, including Sialyl-Lewis(x). These results disclose the molecular basis for the altered pattern of glycan structures observed in the mice gastric mucosa. The gene transcription alterations and the induced glycophenotypic changes observed in the gastric mucosa contribute for the understanding of the molecular mechanisms underlying the role of Pteridium aquilinum in the gastric carcinogenesis process. |
| doi_str_mv | 10.1371/journal.pone.0038353 |
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Epidemiological studies have shown an association between bracken fern exposure and gastric cancer development in humans. The biological effects of exposure to this plant within the gastric carcinogenesis process are not fully understood. In the present work, effects in the gastric mucosa of mice treated with Pteridium aquilinum were evaluated, as well as molecular mechanisms underlying the synergistic role with Helicobacter pylori infection. Our results showed that exposure to Pteridium aquilinum induces histomorphological modifications including increased expression of acidic glycoconjugates in the gastric mucosa. The transcriptome analysis of gastric mucosa showed that upon exposure to Pteridium aquilinum several glycosyltransferase genes were differently expressed, including Galntl4, C1galt1 and St3gal2, that are mainly involved in the biosynthesis of simple mucin-type carbohydrate antigens. Concomitant treatment with Pteridium aquilinum and infection with Helicobacter pylori also resulted in differently expressed glycosyltransferase genes underlying the biosynthesis of terminal sialylated Lewis antigens, including Sialyl-Lewis(x). These results disclose the molecular basis for the altered pattern of glycan structures observed in the mice gastric mucosa. The gene transcription alterations and the induced glycophenotypic changes observed in the gastric mucosa contribute for the understanding of the molecular mechanisms underlying the role of Pteridium aquilinum in the gastric carcinogenesis process.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0038353</identifier><identifier>PMID: 22719879</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Antigens ; Antiulcer agents ; Arrays ; Bayesian analysis ; Biochemistry, Molecular Biology ; Biological effects ; Biology ; Biosynthesis ; Cancer ; Carbohydrate Metabolism ; Carbohydrates ; Carcinogenesis ; Carcinogens ; Cocarcinogenesis ; Epidemiology ; Exposure ; Ferns ; Gastric cancer ; Gastric mucosa ; Gastric Mucosa - drug effects ; Gene expression ; Genes ; Genomics ; Glycan ; Glycoconjugates ; Glycosyltransferase ; Health aspects ; Helicobacter infections ; Helicobacter Infections - complications ; Helicobacter Infections - microbiology ; Helicobacter Infections - pathology ; Helicobacter pylori ; Helicobacter pylori - isolation & purification ; Histopathology ; Human health and pathology ; Immunoglobulins ; Immunohistochemistry ; Immunology ; Infection ; Infections ; Infectious diseases ; Inflammation ; Lewis antigens ; Life Sciences ; Medicine ; Mice ; Molecular modelling ; Mucin ; Mucous membrane ; Pathology ; Phenotype ; Physiological aspects ; Plant Extracts - toxicity ; Pteridium - chemistry ; Pteridium aquilinum ; Stomach cancer ; Stomach Neoplasms - complications ; Stomach Neoplasms - etiology ; Synergistic effect ; Transcription ; Transcription (Genetics)</subject><ispartof>PloS one, 2012-06, Vol.7 (6), p.e38353</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Gomes et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Epidemiological studies have shown an association between bracken fern exposure and gastric cancer development in humans. The biological effects of exposure to this plant within the gastric carcinogenesis process are not fully understood. In the present work, effects in the gastric mucosa of mice treated with Pteridium aquilinum were evaluated, as well as molecular mechanisms underlying the synergistic role with Helicobacter pylori infection. Our results showed that exposure to Pteridium aquilinum induces histomorphological modifications including increased expression of acidic glycoconjugates in the gastric mucosa. The transcriptome analysis of gastric mucosa showed that upon exposure to Pteridium aquilinum several glycosyltransferase genes were differently expressed, including Galntl4, C1galt1 and St3gal2, that are mainly involved in the biosynthesis of simple mucin-type carbohydrate antigens. Concomitant treatment with Pteridium aquilinum and infection with Helicobacter pylori also resulted in differently expressed glycosyltransferase genes underlying the biosynthesis of terminal sialylated Lewis antigens, including Sialyl-Lewis(x). These results disclose the molecular basis for the altered pattern of glycan structures observed in the mice gastric mucosa. The gene transcription alterations and the induced glycophenotypic changes observed in the gastric mucosa contribute for the understanding of the molecular mechanisms underlying the role of Pteridium aquilinum in the gastric carcinogenesis process.</description><subject>Animals</subject><subject>Antigens</subject><subject>Antiulcer agents</subject><subject>Arrays</subject><subject>Bayesian analysis</subject><subject>Biochemistry, Molecular Biology</subject><subject>Biological effects</subject><subject>Biology</subject><subject>Biosynthesis</subject><subject>Cancer</subject><subject>Carbohydrate Metabolism</subject><subject>Carbohydrates</subject><subject>Carcinogenesis</subject><subject>Carcinogens</subject><subject>Cocarcinogenesis</subject><subject>Epidemiology</subject><subject>Exposure</subject><subject>Ferns</subject><subject>Gastric cancer</subject><subject>Gastric mucosa</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genomics</subject><subject>Glycan</subject><subject>Glycoconjugates</subject><subject>Glycosyltransferase</subject><subject>Health aspects</subject><subject>Helicobacter infections</subject><subject>Helicobacter Infections - 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Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gomes, Joana</au><au>Magalhães, Ana</au><au>Carvalho, Ana S</au><au>Hernandez, Gilberto E</au><au>Papp, Suzanne L</au><au>Head, Steven R</au><au>Michel, Valérie</au><au>David, Leonor</au><au>Gärtner, Fátima</au><au>Touati, Eliette</au><au>Reis, Celso A</au><au>Yamaoka, Yoshio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glycophenotypic alterations induced by Pteridium aquilinum in mice gastric mucosa: synergistic effect with Helicobacter pylori infection</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-06-13</date><risdate>2012</risdate><volume>7</volume><issue>6</issue><spage>e38353</spage><pages>e38353-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The bracken fern Pteridium aquilinum is a plant known to be carcinogenic to animals. Epidemiological studies have shown an association between bracken fern exposure and gastric cancer development in humans. The biological effects of exposure to this plant within the gastric carcinogenesis process are not fully understood. In the present work, effects in the gastric mucosa of mice treated with Pteridium aquilinum were evaluated, as well as molecular mechanisms underlying the synergistic role with Helicobacter pylori infection. Our results showed that exposure to Pteridium aquilinum induces histomorphological modifications including increased expression of acidic glycoconjugates in the gastric mucosa. The transcriptome analysis of gastric mucosa showed that upon exposure to Pteridium aquilinum several glycosyltransferase genes were differently expressed, including Galntl4, C1galt1 and St3gal2, that are mainly involved in the biosynthesis of simple mucin-type carbohydrate antigens. Concomitant treatment with Pteridium aquilinum and infection with Helicobacter pylori also resulted in differently expressed glycosyltransferase genes underlying the biosynthesis of terminal sialylated Lewis antigens, including Sialyl-Lewis(x). These results disclose the molecular basis for the altered pattern of glycan structures observed in the mice gastric mucosa. The gene transcription alterations and the induced glycophenotypic changes observed in the gastric mucosa contribute for the understanding of the molecular mechanisms underlying the role of Pteridium aquilinum in the gastric carcinogenesis process.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22719879</pmid><doi>10.1371/journal.pone.0038353</doi><tpages>e38353</tpages><orcidid>https://orcid.org/0000-0003-4207-9258</orcidid><orcidid>https://orcid.org/0000-0002-3450-1773</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-06, Vol.7 (6), p.e38353 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1325027055 |
| source | PubMed (Medline); Publicly Available Content Database (Proquest) (PQ_SDU_P3) |
| subjects | Animals Antigens Antiulcer agents Arrays Bayesian analysis Biochemistry, Molecular Biology Biological effects Biology Biosynthesis Cancer Carbohydrate Metabolism Carbohydrates Carcinogenesis Carcinogens Cocarcinogenesis Epidemiology Exposure Ferns Gastric cancer Gastric mucosa Gastric Mucosa - drug effects Gene expression Genes Genomics Glycan Glycoconjugates Glycosyltransferase Health aspects Helicobacter infections Helicobacter Infections - complications Helicobacter Infections - microbiology Helicobacter Infections - pathology Helicobacter pylori Helicobacter pylori - isolation & purification Histopathology Human health and pathology Immunoglobulins Immunohistochemistry Immunology Infection Infections Infectious diseases Inflammation Lewis antigens Life Sciences Medicine Mice Molecular modelling Mucin Mucous membrane Pathology Phenotype Physiological aspects Plant Extracts - toxicity Pteridium - chemistry Pteridium aquilinum Stomach cancer Stomach Neoplasms - complications Stomach Neoplasms - etiology Synergistic effect Transcription Transcription (Genetics) |
| title | Glycophenotypic alterations induced by Pteridium aquilinum in mice gastric mucosa: synergistic effect with Helicobacter pylori infection |
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