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Expression of miRNAs and their cooperative regulation of the pathophysiology in traumatic brain injury
Traumatic brain injury (TBI) is a leading cause of injury-related death and disability worldwide. Effective treatment for TBI is limited and many TBI patients suffer from neuropsychiatric sequelae. The molecular and cellular mechanisms underlying the neuronal damage and impairment of mental abilitie...
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Published in: | PloS one 2012-06, Vol.7 (6), p.e39357-e39357 |
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description | Traumatic brain injury (TBI) is a leading cause of injury-related death and disability worldwide. Effective treatment for TBI is limited and many TBI patients suffer from neuropsychiatric sequelae. The molecular and cellular mechanisms underlying the neuronal damage and impairment of mental abilities following TBI are largely unknown. Here we used the next generation sequencing platform to delineate miRNA transcriptome changes in the hippocampus at 24 hours and 7 days following TBI in the rat controlled cortical impact injury (CCI) model, and developed a bioinformatic analysis to identify cellular activities that are regulated by miRNAs differentially expressed in the CCI brains. The results of our study indicate that distinct sets of miRNAs are regulated at different post-traumatic times, and suggest that multiple miRNA species cooperatively regulate cellular pathways for the pathological changes and management of brain injury. The distinctive miRNAs expression profiles at different post-CCI times may be used as molecular signatures to assess TBI progression. In addition to known pathophysiological changes, our study identifies many other cellular pathways that are subjected to modification by differentially expressed miRNAs in TBI brains. These pathways can potentially be targeted for development of novel TBI treatment. |
doi_str_mv | 10.1371/journal.pone.0039357 |
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Effective treatment for TBI is limited and many TBI patients suffer from neuropsychiatric sequelae. The molecular and cellular mechanisms underlying the neuronal damage and impairment of mental abilities following TBI are largely unknown. Here we used the next generation sequencing platform to delineate miRNA transcriptome changes in the hippocampus at 24 hours and 7 days following TBI in the rat controlled cortical impact injury (CCI) model, and developed a bioinformatic analysis to identify cellular activities that are regulated by miRNAs differentially expressed in the CCI brains. The results of our study indicate that distinct sets of miRNAs are regulated at different post-traumatic times, and suggest that multiple miRNA species cooperatively regulate cellular pathways for the pathological changes and management of brain injury. The distinctive miRNAs expression profiles at different post-CCI times may be used as molecular signatures to assess TBI progression. In addition to known pathophysiological changes, our study identifies many other cellular pathways that are subjected to modification by differentially expressed miRNAs in TBI brains. These pathways can potentially be targeted for development of novel TBI treatment.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0039357</identifier><identifier>PMID: 22761770</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Anatomy & physiology ; Animals ; Apoptosis ; Bayesian analysis ; Binding sites ; Bioinformatics ; Biology ; Brain ; Brain injuries ; Brain Injuries - genetics ; Brain Injuries - metabolism ; Brain Injuries - physiopathology ; Chondroitin sulfate ; Complications ; Cortex ; Developmental biology ; Gene expression ; Genomes ; Head injuries ; Health sciences ; Hippocampus - injuries ; Hippocampus - metabolism ; Hippocampus - physiopathology ; Injury analysis ; Injury prevention ; Ischemia ; Male ; Medicine ; Memory ; Mental health ; MicroRNA ; MicroRNAs ; MicroRNAs - genetics ; MicroRNAs - metabolism ; miRNA ; Neurons ; Neurons - metabolism ; Pathology ; Pediatrics ; Physiology ; Rats ; Rodents ; Time Factors ; Transcriptome ; Traumatic brain injury ; Trends</subject><ispartof>PloS one, 2012-06, Vol.7 (6), p.e39357-e39357</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012. 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These pathways can potentially be targeted for development of novel TBI treatment.</description><subject>Analysis</subject><subject>Anatomy & physiology</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Bayesian analysis</subject><subject>Binding sites</subject><subject>Bioinformatics</subject><subject>Biology</subject><subject>Brain</subject><subject>Brain injuries</subject><subject>Brain Injuries - genetics</subject><subject>Brain Injuries - metabolism</subject><subject>Brain Injuries - physiopathology</subject><subject>Chondroitin sulfate</subject><subject>Complications</subject><subject>Cortex</subject><subject>Developmental biology</subject><subject>Gene expression</subject><subject>Genomes</subject><subject>Head injuries</subject><subject>Health sciences</subject><subject>Hippocampus - injuries</subject><subject>Hippocampus - metabolism</subject><subject>Hippocampus - physiopathology</subject><subject>Injury analysis</subject><subject>Injury prevention</subject><subject>Ischemia</subject><subject>Male</subject><subject>Medicine</subject><subject>Memory</subject><subject>Mental health</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - 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Effective treatment for TBI is limited and many TBI patients suffer from neuropsychiatric sequelae. The molecular and cellular mechanisms underlying the neuronal damage and impairment of mental abilities following TBI are largely unknown. Here we used the next generation sequencing platform to delineate miRNA transcriptome changes in the hippocampus at 24 hours and 7 days following TBI in the rat controlled cortical impact injury (CCI) model, and developed a bioinformatic analysis to identify cellular activities that are regulated by miRNAs differentially expressed in the CCI brains. The results of our study indicate that distinct sets of miRNAs are regulated at different post-traumatic times, and suggest that multiple miRNA species cooperatively regulate cellular pathways for the pathological changes and management of brain injury. The distinctive miRNAs expression profiles at different post-CCI times may be used as molecular signatures to assess TBI progression. 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subjects | Analysis Anatomy & physiology Animals Apoptosis Bayesian analysis Binding sites Bioinformatics Biology Brain Brain injuries Brain Injuries - genetics Brain Injuries - metabolism Brain Injuries - physiopathology Chondroitin sulfate Complications Cortex Developmental biology Gene expression Genomes Head injuries Health sciences Hippocampus - injuries Hippocampus - metabolism Hippocampus - physiopathology Injury analysis Injury prevention Ischemia Male Medicine Memory Mental health MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Neurons Neurons - metabolism Pathology Pediatrics Physiology Rats Rodents Time Factors Transcriptome Traumatic brain injury Trends |
title | Expression of miRNAs and their cooperative regulation of the pathophysiology in traumatic brain injury |
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