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Expression of miRNAs and their cooperative regulation of the pathophysiology in traumatic brain injury

Traumatic brain injury (TBI) is a leading cause of injury-related death and disability worldwide. Effective treatment for TBI is limited and many TBI patients suffer from neuropsychiatric sequelae. The molecular and cellular mechanisms underlying the neuronal damage and impairment of mental abilitie...

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Published in:PloS one 2012-06, Vol.7 (6), p.e39357-e39357
Main Authors: Hu, Zhonghua, Yu, Danni, Almeida-Suhett, Camila, Tu, Kang, Marini, Ann M, Eiden, Lee, Braga, Maria F, Zhu, Jun, Li, Zheng
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description Traumatic brain injury (TBI) is a leading cause of injury-related death and disability worldwide. Effective treatment for TBI is limited and many TBI patients suffer from neuropsychiatric sequelae. The molecular and cellular mechanisms underlying the neuronal damage and impairment of mental abilities following TBI are largely unknown. Here we used the next generation sequencing platform to delineate miRNA transcriptome changes in the hippocampus at 24 hours and 7 days following TBI in the rat controlled cortical impact injury (CCI) model, and developed a bioinformatic analysis to identify cellular activities that are regulated by miRNAs differentially expressed in the CCI brains. The results of our study indicate that distinct sets of miRNAs are regulated at different post-traumatic times, and suggest that multiple miRNA species cooperatively regulate cellular pathways for the pathological changes and management of brain injury. The distinctive miRNAs expression profiles at different post-CCI times may be used as molecular signatures to assess TBI progression. In addition to known pathophysiological changes, our study identifies many other cellular pathways that are subjected to modification by differentially expressed miRNAs in TBI brains. These pathways can potentially be targeted for development of novel TBI treatment.
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subjects Analysis
Anatomy & physiology
Animals
Apoptosis
Bayesian analysis
Binding sites
Bioinformatics
Biology
Brain
Brain injuries
Brain Injuries - genetics
Brain Injuries - metabolism
Brain Injuries - physiopathology
Chondroitin sulfate
Complications
Cortex
Developmental biology
Gene expression
Genomes
Head injuries
Health sciences
Hippocampus - injuries
Hippocampus - metabolism
Hippocampus - physiopathology
Injury analysis
Injury prevention
Ischemia
Male
Medicine
Memory
Mental health
MicroRNA
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
Neurons
Neurons - metabolism
Pathology
Pediatrics
Physiology
Rats
Rodents
Time Factors
Transcriptome
Traumatic brain injury
Trends
title Expression of miRNAs and their cooperative regulation of the pathophysiology in traumatic brain injury
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