Epigenetic regulation of fatty acid amide hydrolase in Alzheimer disease

Alzheimer disease (AD) is a progressive, degenerative and irreversible neurological disorder with few therapies available. In search for new potential targets, increasing evidence suggests a role for the endocannabinoid system (ECS) in the regulation of neurodegenerative processes. We have studied t...

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Bibliographic Details
Published in:PloS one 2012-06, Vol.7 (6), p.e39186-e39186
Main Authors: D'Addario, Claudio, Di Francesco, Andrea, Arosio, Beatrice, Gussago, Cristina, Dell'Osso, Bernardo, Bari, Monica, Galimberti, Daniela, Scarpini, Elio, Altamura, A Carlo, Mari, Daniela, Maccarrone, Mauro
Format: Article
Language:English
Subjects:
Activities of daily living
Advertising executives
Aged
Aging
Alzheimer Disease - genetics
Alzheimer's disease
Amidohydrolases - genetics
Base Sequence
Biology
Biomarkers
Brain research
Cannabinoids
Cytochrome
Deoxyribonucleic acid
DNA
DNA methylation
DNA Primers
Endocannabinoid system
Epigenesis, Genetic
Epigenetic inheritance
Epigenetics
Fatty acids
Fatty-acid amide hydrolase
Female
Gene expression
Genes
Geriatrics
Humans
Hydrolase
Hydrolases
Leukocytes (mononuclear)
Load matching
Localization
Male
Medicine
Memory
Messenger RNA
Metabolism
Methylation
Middle Aged
Nervous system
Neurodegeneration
Neurodegenerative diseases
Neurophysiology
Pathogenesis
Peripheral blood mononuclear cells
Regulations
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Summary:Alzheimer disease (AD) is a progressive, degenerative and irreversible neurological disorder with few therapies available. In search for new potential targets, increasing evidence suggests a role for the endocannabinoid system (ECS) in the regulation of neurodegenerative processes. We have studied the gene expression status and the epigenetic regulation of ECS components in peripheral blood mononuclear cells (PBMCs) of subjects with late-onset AD (LOAD) and age-matched controls (CT). We found an increase in fatty acid amide hydrolase (faah) gene expression in LOAD subjects (2.30 ± 0.48) when compared to CT (1.00 ± 0.14; *p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0039186