Long-term occupational exposure to organic solvents affects color vision, contrast sensitivity and visual fields

The purpose of this study was to evaluate the visual outcome of chronic occupational exposure to a mixture of organic solvents by measuring color discrimination, achromatic contrast sensitivity and visual fields in a group of gas station workers. We tested 25 workers (20 males) and 25 controls with...

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Bibliographic Details
Published in:PloS one 2012-08, Vol.7 (8), p.e42961
Main Authors: Costa, Thiago Leiros, Barboni, Mirella Telles Salgueiro, Moura, Ana Laura de Araújo, Bonci, Daniela Maria Oliveira, Gualtieri, Mirella, de Lima Silveira, Luiz Carlos, Ventura, Dora Fix
Format: Article
Language:English
Subjects:
Adult
Automation
Biology
Chronic exposure
Color
Color sensitivity
Color vision
Color Vision - drug effects
Color Vision Defects - chemically induced
Compounds
Contrast Sensitivity - drug effects
Defects
Eccentricity
Ellipticity
Ethanol
Exposure
Eye
Fovea
Gasoline
Genetic analysis
Hazardous materials
Hazardous substances
Humans
Hydrocarbons
Male
Males
Medicine
Middle Aged
Neurotoxicity
Occupational exposure
Occupational Exposure - adverse effects
Occupational health
Organic Chemicals - toxicity
Organic solvents
Retina
Sensitivity
Sensitivity analysis
Service stations
Service stations (Automotive)
Solvents
Solvents - toxicity
Thresholds
Visual discrimination
Visual field
Visual fields
Visual Fields - drug effects
Visual impairment
Workers
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Summary:The purpose of this study was to evaluate the visual outcome of chronic occupational exposure to a mixture of organic solvents by measuring color discrimination, achromatic contrast sensitivity and visual fields in a group of gas station workers. We tested 25 workers (20 males) and 25 controls with no history of chronic exposure to solvents (10 males). All participants had normal ophthalmologic exams. Subjects had worked in gas stations on an average of 9.6 ± 6.2 years. Color vision was evaluated with the Lanthony D15d and Cambridge Colour Test (CCT). Visual field assessment consisted of white-on-white 24-2 automatic perimetry (Humphrey II-750i). Contrast sensitivity was measured for sinusoidal gratings of 0.2, 0.5, 1.0, 2.0, 5.0, 10.0 and 20.0 cycles per degree (cpd). Results from both groups were compared using the Mann-Whitney U test. The number of errors in the D15d was higher for workers relative to controls (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0042961