Developing a gene expression model for predicting ventilator-associated pneumonia in trauma patients: a pilot study

Ventilator-associated pneumonia (VAP) carries significant mortality and morbidity. Predicting which patients will become infected could lead to measures to reduce the incidence of VAP. The goal was to begin constructing a model for VAP prediction in critically-injured trauma patients, and to identif...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2012-08, Vol.7 (8), p.e42065-e42065
Main Authors: Swanson, Joseph M, Wood, G Christopher, Xu, Lijing, Tang, Lisa E, Meibohm, Bernd, Homayouni, Ramin, Croce, Martin A, Fabian, Timothy C
Format: Article
Language:English
Subjects:
ADAM8 protein
Adult
Bacterial infections
Bioinformatics
Biology
Blood
Blood cells
Cluster analysis
Clustering
Comparative analysis
Computer Science
Cytokines
Female
Functional analysis
Gene expression
Gene Expression Profiling
Genes
Health aspects
Humans
Infections
Injuries
Intensive care
Intensive Care Units
Ion channels (cyclic nucleotide-gated)
Kinases
Lipopolysaccharides
Male
Medical research
Medicine
Middle Aged
Mitogens
Morbidity
Mortality
Neutrophils
Patients
Pharmaceutical sciences
Pharmacy
Pilot Projects
Pneumonia
Pneumonia, Ventilator-Associated - genetics
Predictions
Principal components analysis
Prognosis
Proteases
Regression analysis
Regression models
Sepsis
Surgery
Trauma
Variance analysis
Ventilator-associated pneumonia
Ventilators
Wounds and Injuries - complications
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ventilator-associated pneumonia (VAP) carries significant mortality and morbidity. Predicting which patients will become infected could lead to measures to reduce the incidence of VAP. The goal was to begin constructing a model for VAP prediction in critically-injured trauma patients, and to identify differentially expressed genes in patients who go on to develop VAP compared to similar patients who do not. Gene expression profiles of lipopolysaccharide stimulated blood cells in critically injured trauma patients that went on to develop ventilator-associated pneumonia (n=10) was compared to those that never developed the infection (n=10). Eight hundred and ten genes were differentially expressed between the two groups (ANOVA, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0042065