Comparative study of esophageal stent and feeding gastrostomy/jejunostomy for tracheoesophageal fistula caused by esophageal squamous cell carcinoma

• Published in: PloS one 2012-08, Vol.7 (8), p.e42766-e42766
• Main Authors: Chen, Yen-Hao, Li, Shau-Hsuan, Chiu, Yi-Chun, Lu, Hung-I, Huang, Cheng-Hua, Rau, Kun-Ming, Liu, Chien-Ting
• Format: Article
• Language: English
• Subjects: Albumin; Body weight; Body weight loss; Cancer therapies; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - pathology; Care and treatment; Chemotherapy; Comparative analysis; Comparative studies; Diagnosis; Endoscopy; Esophageal cancer; Esophageal Neoplasms - drug therapy; Esophageal Neoplasms - pathology; Esophagus; Esophagus - surgery; Feeding; Feeding Methods - adverse effects; Fistula; Fistulae; Fistulas; Gastrostomy - adverse effects; Health aspects; Hematology; Hospitals; Humans; Implants; Jejunostomy - adverse effects; Medical diagnosis; Medical prognosis; Medicine; Metals; Middle Aged; Nutrition; Oncology; Ostomy; Parenteral nutrition; Patients; Physicians; Prognosis; Prostheses; Radiation therapy; Retrospective Studies; Serum albumin; Squamous cell carcinoma; Stents; Stents - adverse effects; Surgical implants; Survival; Survival Analysis; Tomography; Tracheoesophageal Fistula - diagnosis; Tracheoesophageal Fistula - etiology; Tracheoesophageal Fistula - surgery; Tracheoesophageal Fistula - therapy; Treatment Outcome
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0042766

A malignant tracheoesophageal/bronchoesophageal fistula (TEF) is a life-threatening complication of esophageal squamous cell carcinoma. A feeding gastrostomy/jejunostomy had been the most common treatment method for patients with TEF before the era of stenting. The aim of this retrospective study is to compare the prognosis of esophageal squamous cell carcinoma patients with TEF treated with an esophageal metallic stent to those treated with a feeding gastrostomy/jejunostomy. We retrospectively reviewed a total of 1011 patients with esophageal squamous cell carcinoma between 1996 and 2011 at Kaohsiung Chang Gung Memorial Hospital, and 86 patients with TEF (8.5%) were identified. The overall survival and other clinical data were compared between 30 patients treated with an esophageal metallic stent and 35 patients treated with a feeding gastrostomy/jejunostomy. Among the 65 patients receiving either an esophageal metallic stent or a feeding gastrostomy/jejunostomy, univariate analysis showed that treatment modality with an esophageal metallic stent (P = 0.007) and radiotherapy treatment after fistula diagnosis (P = 0.04) were predictive of superior overall survival. In the multivariate comparison, treatment modality with an esophageal metallic stent (P = 0.026, odds ratio: 1.859) represented the independent predictive factor of superior overall survival. There were no significant differences between groups in mean decrease in serum albumin or mean body weight loss. Compared to the feeding gastrostomy/jejunostomy group, a significantly higher proportion of patients in the stenting group (53% versus 14%, P = 0.001) were able to receive chemotherapy within 30 days after fistula diagnosis, indicating better infection control in the stenting group. Compared with a feeding gastrostomy/jejunostomy, an esophageal metallic stent significantly improves overall survival in patients with malignant TEF in our retrospective analysis. Esophageal metallic stent placement may be considered the first-line of treatment for patients with malignant TEF.