Altered spontaneous activity in anisometropic amblyopia subjects: revealed by resting-state FMRI

Amblyopia, also known as lazy eye, usually occurs during early childhood and results in poor or blurred vision. Recent neuroimaging studies have found cortical structural/functional abnormalities in amblyopia. However, until now, it was still not known whether the spontaneous activity of the brain c...

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Published in:PloS one 2012-08, Vol.7 (8), p.e43373
Main Authors: Lin, Xiaoming, Ding, Kun, Liu, Yong, Yan, Xiaohe, Song, Shaojie, Jiang, Tianzi
Format: Article
Language:English
Subjects:
Abnormalities
Adolescent
Adult
Alzheimer's disease
Amblyopia
Amblyopia - pathology
Auditory plasticity
Biology
Brain
Brain mapping
Care and treatment
Cerebellum
Children
Comparative analysis
Cortex (auditory)
Cortex (frontal)
Cortex (occipital)
Cortex (parietal)
Cortex (somatosensory)
Cortex (temporal)
Development and progression
Diagnosis
Female
Frontal gyrus
Functional magnetic resonance imaging
Homogeneity
Humans
Laboratories
Magnetic resonance
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medical imaging
Medicine
Morphology
Neuroimaging
Neurology
Pattern recognition
Prefrontal cortex
Putamen
Schizophrenia
Somatosensory cortex
Structure-function relationships
Studies
Superior temporal gyrus
Temporal gyrus
Temporal lobe
Tomography
Vision
Young Adult
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Ding, Kun
Liu, Yong
Yan, Xiaohe
Song, Shaojie
Jiang, Tianzi
description Amblyopia, also known as lazy eye, usually occurs during early childhood and results in poor or blurred vision. Recent neuroimaging studies have found cortical structural/functional abnormalities in amblyopia. However, until now, it was still not known whether the spontaneous activity of the brain changes in amblyopia subjects. In the present study, regional homogeneity (ReHo), a measure of the homogeneity of functional magnetic resonance imaging signals, was used for the first time to investigate changes in resting-state local spontaneous brain activity in individuals with anisometropic amblyopia. Compared with age- and gender-matched subjects with normal vision, the anisometropic amblyopia subjects showed decreased ReHo of spontaneous brain activity in the right precuneus, the left medial prefrontal cortex, the left inferior frontal gyrus, and the left cerebellum, and increased ReHo of spontaneous brain activity was found in the bilateral conjunction area of the postcentral and precentral gyri, the left paracentral lobule, the left superior temporal gyrus, the left fusiform gyrus, the conjunction area of the right insula, putamen and the right middle occipital gyrus. The observed decreases in ReHo may reflect decreased visuo-motor processing ability, and the increases in ReHo in the somatosensory cortices, the motor areas and the auditory area may indicate compensatory plasticity in amblyopia.
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Recent neuroimaging studies have found cortical structural/functional abnormalities in amblyopia. However, until now, it was still not known whether the spontaneous activity of the brain changes in amblyopia subjects. In the present study, regional homogeneity (ReHo), a measure of the homogeneity of functional magnetic resonance imaging signals, was used for the first time to investigate changes in resting-state local spontaneous brain activity in individuals with anisometropic amblyopia. Compared with age- and gender-matched subjects with normal vision, the anisometropic amblyopia subjects showed decreased ReHo of spontaneous brain activity in the right precuneus, the left medial prefrontal cortex, the left inferior frontal gyrus, and the left cerebellum, and increased ReHo of spontaneous brain activity was found in the bilateral conjunction area of the postcentral and precentral gyri, the left paracentral lobule, the left superior temporal gyrus, the left fusiform gyrus, the conjunction area of the right insula, putamen and the right middle occipital gyrus. 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subjects Abnormalities
Adolescent
Adult
Alzheimer's disease
Amblyopia
Amblyopia - pathology
Auditory plasticity
Biology
Brain
Brain mapping
Care and treatment
Cerebellum
Children
Comparative analysis
Cortex (auditory)
Cortex (frontal)
Cortex (occipital)
Cortex (parietal)
Cortex (somatosensory)
Cortex (temporal)
Development and progression
Diagnosis
Female
Frontal gyrus
Functional magnetic resonance imaging
Homogeneity
Humans
Laboratories
Magnetic resonance
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medical imaging
Medicine
Morphology
Neuroimaging
Neurology
Pattern recognition
Prefrontal cortex
Putamen
Schizophrenia
Somatosensory cortex
Structure-function relationships
Studies
Superior temporal gyrus
Temporal gyrus
Temporal lobe
Tomography
Vision
Young Adult
title Altered spontaneous activity in anisometropic amblyopia subjects: revealed by resting-state FMRI
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