Lasting consequences of traumatic events on behavioral and skeletal parameters in a mouse model for post-traumatic stress disorder (PTSD)

Post-traumatic stress disorder (PTSD) is an anxiety disorder that not only affects mental health, but may also affect bone health. However, there have been no studies to examine the direct relationship between PTSD and bone. We employed electric shocks in mice to simulate traumatic events that cause...

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Bibliographic Details
Published in:PloS one 2012-08, Vol.7 (8), p.e42684
Main Authors: Yu, Hongrun, Watt, Heather, Kesavan, Chandrasekhar, Johnson, Patrick J, Wergedal, Jon E, Mohan, Subburaman
Format: Article
Language:English
Subjects:
Analysis
Animals
Anxiety
Anxiety - chemically induced
Behavior, Animal - drug effects
Biology
Bone and Bones - drug effects
Bone and Bones - physiology
Bone density
Bone Density - drug effects
Bone mass
Bone mineral content
Bone mineral density
Bones
Carbolines - pharmacology
Care and treatment
Complications and side effects
Computer simulation
Conditioning
Disease Models, Animal
Fear conditioning
Female
Femur
Freezing
Health aspects
Injection
Injections
Medicine
Memory
Mental depression
Mental disorders
Mental health
Mice
Mice, Inbred C57BL
Post traumatic stress disorder
Posttraumatic stress disorder
Rodents
Social and Behavioral Sciences
Spine
Stress Disorders, Post-Traumatic - physiopathology
Stress, Psychological - chemically induced
Stress, Psychological - etiology
Stress, Psychological - physiopathology
Tibia
Time Factors
Tonic immobility
Vertebrae
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Summary:Post-traumatic stress disorder (PTSD) is an anxiety disorder that not only affects mental health, but may also affect bone health. However, there have been no studies to examine the direct relationship between PTSD and bone. We employed electric shocks in mice to simulate traumatic events that cause PTSD. We also injected the anxiogenic drug FG-7142 prior to electric shocks. Electric shocks created lasting conditioned fear memory in all mice. In young mice, electric shocks elicited not only behavioral response but also skeletal response, and injection of FG-7142 appeared to increase both types of response. For example in behavioral response within the first week, mice shocked alone froze an average of 6.2 sec in 10 sec tests, and mice injected with FG-7142 froze 7.6 sec, both significantly different (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0042684