Intracerebral hemorrhages in adults with community associated bacterial meningitis in adults: should we reconsider anticoagulant therapy?

To study the incidence, clinical presentation and outcome of intracranial hemorrhagic complications in adult patients with community associated bacterial meningitis. Nationwide prospective cohort study from all hospitals in the Netherlands, from 1 March 2006, through 31 December 2010. Of the 860 epi...

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Bibliographic Details
Published in:PloS one 2012-09, Vol.7 (9), p.e45271
Main Authors: Mook-Kanamori, Barry B, Fritz, Daan, Brouwer, Matthijs C, van der Ende, Arie, van de Beek, Diederik
Format: Article
Language:English
Subjects:
Adult
Adults
Aged
Anticoagulants
Anticoagulants - adverse effects
Bacteria
Bacterial meningitis
Biology
Cerebral Hemorrhage - drug therapy
Cerebral Hemorrhage - epidemiology
Cerebral Hemorrhage - etiology
Cerebral Hemorrhage - mortality
Cohort Studies
Communities
Community-Acquired Infections - complications
Community-Acquired Infections - drug therapy
Community-Acquired Infections - epidemiology
Community-Acquired Infections - mortality
Complications
Confidence intervals
Endocarditis
Female
Glucose
Health aspects
Hemorrhage
Humans
Incidence
Laboratories
Listeria
Listeria monocytogenes
Male
Medical personnel
Medicine
Meningitis
Meningitis, Bacterial - complications
Meningitis, Bacterial - drug therapy
Meningitis, Bacterial - epidemiology
Meningitis, Bacterial - mortality
Middle Aged
Mortality
Netherlands - epidemiology
Neurology
Patients
Physicians
Pneumonia
Prognosis
Pseudomonas aeruginosa
Risk Factors
Staphylococcus aureus
Streptococcus infections
Stroke
Survival Rate
Therapy
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Summary:To study the incidence, clinical presentation and outcome of intracranial hemorrhagic complications in adult patients with community associated bacterial meningitis. Nationwide prospective cohort study from all hospitals in the Netherlands, from 1 March 2006, through 31 December 2010. Of the 860 episodes of bacterial meningitis that were included, 24 were diagnosed with intracranial hemorrhagic complications: 8 upon presentation and 16 during clinical course. Clinical presentation between patients with or without intracranial hemorrhage was similar. Causative bacteria were Streptococcus pneumoniae in 16 patients (67%), Staphylococcus aureus in 5 (21%), Pseudomonas aeruginosa and Listeria monocytogenes both in 1 patient (4%). Occurrence of intracranial hemorrhage was associated with death (63% vs. 15%, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0045271