Both baseline clinical factors and genetic polymorphisms influence the development of severe functional status in ankylosing spondylitis

Functional severity in ankylosing spondylitis (AS) patients is variable and difficult to predict early. The aim of our study was to assess whether a combination of baseline clinical factors and genetic markers may predict the development of severe functional status in AS. We performed a cross-sectio...

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Bibliographic Details
Published in:PloS one 2012-09, Vol.7 (9), p.e43428-e43428
Main Authors: Schiotis, Ruxandra, Bartolomé, Nerea, Sánchez, Alejandra, Szczypiorska, Magdalena, Sanz, Jesús, Cuende, Eduardo, Collantes Estevez, Eduardo, Martínez, Antonio, Tejedor, Diego, Artieda, Marta, Buzoianu, Anca, Mulero, Juan
Format: Article
Language:English
Subjects:
Ankylosing spondylitis
Antigens
Arthritis
Biology
Chromosomes
Deoxyribonucleic acid
Diabetes
DNA
Family medical history
Female
Gene expression
Gene frequency
Genetic aspects
Genetic markers
Genotypes
Hospitals
Humans
Male
Medical research
Medicine
Middle Aged
Neck
Pain
Patients
Pharmacy
Polymorphism, Single Nucleotide - genetics
Regression analysis
Rheumatology
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Spain
Spondylitis
Spondylitis, Ankylosing - genetics
Spondylitis, Ankylosing - pathology
Spondylitis, Ankylosing - physiopathology
Spondyloarthropathy
Statistical analysis
Citations: Items that cite this one
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Summary:Functional severity in ankylosing spondylitis (AS) patients is variable and difficult to predict early. The aim of our study was to assess whether a combination of baseline clinical factors and genetic markers may predict the development of severe functional status in AS. We performed a cross-sectional association study on AS patients included in the Spanish National Registry of Spondyloarthropathies--REGISPONSER. Bath Ankylosing Spondylitis Functional Index (BASFI) was standardized by adjusting for disease duration since the first symptoms (BASFI/t). We considered as severe functional status the values of BASFI/t in the top of the 60th (p60), 65th (p65), 70th (p70), and 75th (p75) percentile. We selected 384 single nucleotide polymorphisms (SNPs) distributed in 190 genes to be analyzed. The study cohort included 456 patients with mean age 50.8(± 10.5) years and with mean disease duration since first symptoms 24.7 (± 10.1) years. Older age at disease onset and neck pain at baseline showed statistical significant association with severe BASFI/t. Polymorphisms associated in the allele frequencies test with severe BASFI/t in all classifications were: rs2542151 (p60 [P = .04], p65 [P = .04], p70 [P = .001] and p75 [P = .001]) and rs2254441 (p60 [P = .004], p65 [P = .02], p70 [P = .01] and p75 [P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0043428