Slug, twist, and E-cadherin as immunohistochemical biomarkers in meningeal tumors

The overexpression of Twist and Slug and subsequent down-regulation of E-cadherin facilitate the acquirement of invasive growth properties in cancer cells. It is unclear which of these molecules are expressed in mesenchymal tumors in the central nervous system. Here, we investigated 10 cases each of...

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Bibliographic Details
Published in:PloS one 2012-09, Vol.7 (9), p.e46053-e46053
Main Authors: Nagaishi, Masaya, Nobusawa, Sumihito, Tanaka, Yuko, Ikota, Hayato, Yokoo, Hideaki, Nakazato, Yoichi
Format: Article
Language:English
Subjects:
Biological markers
Biology
Biomarkers
Biomarkers, Tumor - analysis
Brain cancer
Cadherins
Cancer
Cell adhesion & migration
Central nervous system
Diagnostic systems
Differential diagnosis
E-cadherin
Genetic aspects
Hemangiopericytoma - diagnosis
Hemangiopericytoma - pathology
Histopathology
Humans
Immunohistochemistry
Invasiveness
Kinases
Medicine
Meningeal Neoplasms - diagnosis
Meningeal Neoplasms - pathology
Meninges
Meningioma
Meningioma - diagnosis
Meningioma - pathology
Mesenchyme
Metastasis
N-Cadherin
Nervous system
Pathology
Physiological aspects
Properties
Risk factors
Snail Family Transcription Factors
Solitary Fibrous Tumors - diagnosis
Solitary Fibrous Tumors - pathology
Transcription Factors
Tumor cells
Tumors
Twist-Related Protein 1
University graduates
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Summary:The overexpression of Twist and Slug and subsequent down-regulation of E-cadherin facilitate the acquirement of invasive growth properties in cancer cells. It is unclear which of these molecules are expressed in mesenchymal tumors in the central nervous system. Here, we investigated 10 cases each of hemangiopericytoma, solitary fibrous tumor, meningothelial, fibrous, angiomatous, and atypical meningiomas, and 5 cases of anaplastic meningioma for Slug, Twist, E-cadherin, and N-cadherin immunoexpression. Nuclear Slug expression was observed in 9/10 (90%) hemangiopericytomas and 5/10 (50%) solitary fibrous tumors, but not in any meningiomas, except for 1 case. Similarly, nuclear Twist expression was more extensive in hemangiopericytomas and solitary fibrous tumors than meningiomas. In contrast to Slug and Twist, the positive expression of E-cadherin was observed in 39/45 (87%) meningiomas, but not in any hemangiopericytomas or solitary fibrous tumors (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0046053