P53 status as a predictive biomarker for patients receiving neoadjuvant radiation-based treatment: a meta-analysis in rectal cancer

Numerous studies have yielded inconsistent results regarding the relationship between p53 status and the response to neoadjuvant radiation-based therapy in patients with rectal cancer. We conducted a meta-analysis to clarify the relationship between p53 status and response to radiation-based therapy...

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Bibliographic Details
Published in:PloS one 2012-09, Vol.7 (9), p.e45388
Main Authors: Chen, Min-Bin, Wu, Xiao-Yang, Yu, Rong, Li, Chen, Wang, Li-Qiang, Shen, Wei, Lu, Pei-Hua
Format: Article
Language:English
Subjects:
Adenocarcinoma
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Apoptosis
Background radiation
Biology
Biomarkers
Biomarkers - metabolism
Cancer
Cancer patients
Cancer therapies
Care and treatment
Cell cycle
Chemoradiotherapy
Chemotherapy
Colorectal cancer
Confidence intervals
Gamma Rays
Gene expression
Gene Expression - drug effects
Gene Expression - radiation effects
Health aspects
Health risk assessment
Hospitals
Humans
Medical ethics
Medical prognosis
Medicine
Meta-analysis
Mutation
Neoadjuvant Therapy
Neoplasm Grading
Oncology
p53 Protein
Patients
Prognosis
Radiation
Radiation therapy
Radiotherapy
Rectal Neoplasms - drug therapy
Rectal Neoplasms - genetics
Rectal Neoplasms - pathology
Rectal Neoplasms - radiotherapy
Rectum
Studies
Surgery
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - metabolism
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Summary:Numerous studies have yielded inconsistent results regarding the relationship between p53 status and the response to neoadjuvant radiation-based therapy in patients with rectal cancer. We conducted a meta-analysis to clarify the relationship between p53 status and response to radiation-based therapy in rectal cancer. A total of 30 previously published eligible studies including 1,830 cases were identified and included in this meta-analysis. Wild-type form of p53 status (low expression of p53 protein and/or wild-type p53 gene) was associated with pathologic response in rectal cancer patients who received neoadjuvant radiation-based therapy (good response: risk ratio [RR] =1.30; 95% confidence intervals [CI] =1.14-1.49; p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0045388