Association between common polymorphism near the MC4R gene and obesity risk: a systematic review and meta-analysis

Genome-wide association studies on Europeans have shown that two polymorphisms (rs17782313, rs12970134) near the melanocortin 4 receptor (MC4R) gene were associated with increased risk of obesity. Subsequently studies among different ethnic populations have shown mixed results with some confirming a...

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Published in:PloS one 2012-09, Vol.7 (9), p.e45731-e45731
Main Authors: Xi, Bo, Chandak, Giriraj R, Shen, Yue, Wang, Qijuan, Zhou, Donghao
Format: Article
Language:English
Subjects:
Adult
Adults
Asian people
Bias
Biology
Body mass index
Body Weight
Cardiovascular disease
Case-Control Studies
Child
Children
Childrens health
Confidence intervals
Epidemiology
Ethnicity
Female
Gene polymorphism
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease
Genome-wide association studies
Genomes
Humans
Male
Maternal & child health
Medicine
Melanocortin
Melanocortin MC4 receptors
Meta-analysis
Middle Aged
Minority & ethnic groups
Models, Statistical
Obesity
Obesity - genetics
Odds Ratio
Polymorphism
Polymorphism, Genetic
Populations
Public health
Receptor, Melanocortin, Type 4 - genetics
Risk
Risk factors
Studies
Subgroups
Systematic review
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Chandak, Giriraj R
Shen, Yue
Wang, Qijuan
Zhou, Donghao
description Genome-wide association studies on Europeans have shown that two polymorphisms (rs17782313, rs12970134) near the melanocortin 4 receptor (MC4R) gene were associated with increased risk of obesity. Subsequently studies among different ethnic populations have shown mixed results with some confirming and others showing inconsistent results, especially among East Asians and Africans. We performed a comprehensive meta-analysis of various studies from different ethnic populations to assess the association of the MC4R polymorphism with obesity risk. We retrieved all published literature that investigated association of MC4R variants with obesity from PubMed and Embase. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects model. A total of 61 studies (80,957 cases/220,223 controls) for rs17782313 polymorphism (or proxy) were included in the meta-analysis. The results suggested that rs17782313 polymorphism was significantly associated with obesity risk (OR=1.18, 95%CI=1.15-1.21, p
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Subsequently studies among different ethnic populations have shown mixed results with some confirming and others showing inconsistent results, especially among East Asians and Africans. We performed a comprehensive meta-analysis of various studies from different ethnic populations to assess the association of the MC4R polymorphism with obesity risk. We retrieved all published literature that investigated association of MC4R variants with obesity from PubMed and Embase. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects model. A total of 61 studies (80,957 cases/220,223 controls) for rs17782313 polymorphism (or proxy) were included in the meta-analysis. The results suggested that rs17782313 polymorphism was significantly associated with obesity risk (OR=1.18, 95%CI=1.15-1.21, p&lt;0.001). Similar trends were observed among subgroups of Europeans and East Asians, adults and children, studies with high quality score, and for each five MC4R polymorphisms independently. The present meta-analysis confirms the significant association of MC4R polymorphism with risk of obesity. 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subjects Adult
Adults
Asian people
Bias
Biology
Body mass index
Body Weight
Cardiovascular disease
Case-Control Studies
Child
Children
Childrens health
Confidence intervals
Epidemiology
Ethnicity
Female
Gene polymorphism
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease
Genome-wide association studies
Genomes
Humans
Male
Maternal & child health
Medicine
Melanocortin
Melanocortin MC4 receptors
Meta-analysis
Middle Aged
Minority & ethnic groups
Models, Statistical
Obesity
Obesity - genetics
Odds Ratio
Polymorphism
Polymorphism, Genetic
Populations
Public health
Receptor, Melanocortin, Type 4 - genetics
Risk
Risk factors
Studies
Subgroups
Systematic review
title Association between common polymorphism near the MC4R gene and obesity risk: a systematic review and meta-analysis
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